Traumatic compaction of the axonal cytoskeleton induces argyrophilia: Histological and theoretical importance

F. Gallyas, O. Farkas, M. Mázló

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

It was earlier established that one of the primary morphopathological consequences of experimental traumatic brain injury is a dramatic reduction in the distances between the neurofilaments (cytoskeletal compaction) inside a number of axon segments that appear to be randomly distributed among normal axons in an otherwise undamaged parenchymal environment. The present results demonstrate that the cytoskeletal compaction instantly induces argyrophilia, thereby rendering possible selective visualisation of the affected axon segments for light microscopy through use of a special silver staining method. On combination of this method with electron microscopy, it was revealed that the cytoskeletal compaction is completed in much shorter times and extends to much longer axon segments than previously assumed.

Original languageEnglish
Pages (from-to)36-42
Number of pages7
JournalActa Neuropathologica
Volume103
Issue number1
DOIs
Publication statusPublished - 2002

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Cytoskeleton
Axons
Silver Staining
Intermediate Filaments
Microscopy
Electron Microscopy
Light

Keywords

  • Axonal pathology
  • Cytoskeletal compaction
  • Electron microscopy
  • Head injury
  • Silver staining

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Traumatic compaction of the axonal cytoskeleton induces argyrophilia : Histological and theoretical importance. / Gallyas, F.; Farkas, O.; Mázló, M.

In: Acta Neuropathologica, Vol. 103, No. 1, 2002, p. 36-42.

Research output: Contribution to journalArticle

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