Trastuzumab (Herceptin) a HER-2-pozitív korai emlorák adjuváns kezelésében

Translated title of the contribution: Trastuzumab (Herceptin) in the adjuvant teatment of HER-2-positive early breast cancer

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Abstract

The prognosis of HER-2-positive breast cancer (characterized by amplification of the HER-2 oncogen and/or overexpression of HER-2 receptor) is unfavourable. Trastuzumab (Herceptin), a monoclonal antibody against HER-2 receptor can improve the outcome of HER-2-positive breast cancer. Up to now this was proven only in advanced disease. Recently five large multicentric phase III adjuvant trials gave level one evidence on the benefit of adjuvant treatment with Herceptin, concerning disease-free survival (DFS) and overall survival (OS). Herceptin has decreased the relative risk of recurrence with about 50% and that of death with nearly 30% in HER-2-positive early breast cancer. Based on these results Herceptin, together with chemotherapy, has been recently approved for the adjuvant treatment of HER-2-positive breast cancer.

Original languageHungarian
Pages (from-to)293-302
Number of pages10
JournalMagyar onkologia
Volume50
Issue number4
Publication statusPublished - Dec 1 2006

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ASJC Scopus subject areas

  • Medicine(all)

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