Transposition of great arteries is associated with increased carotid artery stiffness

Beatrix Mersich, P. Studinger, Z. Lénárd, Krisztina Kadar, M. Kollai

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Transposition of great arteries is the consequence of abnormal aorticopulmonary septation. Animal embryonic data indicate that septation and elastogenesis are related events, but human and clinical data are not available. We tested the hypothesis that large artery elastic function was impaired in patients with transposition of great arteries. We studied 34 patients aged 9 to 19 years, 12±3 years after atrial switch operation; 14 patients aged 7 to 9 years, 8±1 years after arterial switch operation; and 108 healthy control subjects matched for age. Carotid artery diastolic diameter and pulsatile distension were determined by echo wall-tracking; carotid blood pressure was measured by tonometry. Systolic pressure was higher and diastolic pressure was lower in patients than in controls. Patients with atrial and arterial switch repair were compared with their respective controls by 2-factor ANOVA. For patients with atrial switch repair versus control, stiffness index β was 4.9±1.5 versus 3.1±1.0 (P

Original languageEnglish
Pages (from-to)1197-1202
Number of pages6
JournalHypertension
Volume47
Issue number6
DOIs
Publication statusPublished - Jun 2006

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Transposition of Great Vessels
Carotid Arteries
Blood Pressure
Manometry
Analysis of Variance
Healthy Volunteers
Arteries
Arterial Switch Operation

Keywords

  • Arteries
  • Carotid arteries
  • Elasticity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Transposition of great arteries is associated with increased carotid artery stiffness. / Mersich, Beatrix; Studinger, P.; Lénárd, Z.; Kadar, Krisztina; Kollai, M.

In: Hypertension, Vol. 47, No. 6, 06.2006, p. 1197-1202.

Research output: Contribution to journalArticle

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