Transport of muscarinic cholinergic receptors in the sciatic nerve of rat

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Abstract

On the basis of the specific [3H]quinuclidinyl-benzilate binding, the transport of muscarinic cholinergic receptors has been demonstrated in the ventral horn, sciatic nerve and in the 3 mm segments proximal and distal to the ligature of rat sciatic nerves ligated for 24 h (a) without electrolytic lesion, (b) six days after lesion of the spinal ganglia, (c) six days after lesion of the motoric axons, and (d) six days after transection of the sciatic nerve. The distribution of these receptors was also studied in the ventral spinal horn, dorsal root sensory axons, spinal ganglia and sciatic nerve of rabbit. Our results suggest that the receptors are transported in the sciatic nerve of rat. This transport consists of a large anterograde, and a discrete retrograde flow of muscarinic cholinergic receptors. Most of the receptors are possibly synthesized in the motoneuron cell bodies and migrate in the motoric axons; to a lesser extent they may also be synthesized in the cell bodies of the dorsal root ganglia and migrate in the sensory axons of the sciatic nerve.

Original languageEnglish
Pages (from-to)123-126
Number of pages4
JournalNeurochemistry International
Volume6
Issue number1
DOIs
Publication statusPublished - 1984

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Cholinergic Receptors
Muscarinic Receptors
Sciatic Nerve
Axons
Spinal Ganglia
Horns
Quinuclidinyl Benzilate
Spinal Nerves
Spinal Nerve Roots
Motor Neurons
Ligation
Rabbits

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Cellular and Molecular Neuroscience

Cite this

Transport of muscarinic cholinergic receptors in the sciatic nerve of rat. / Gulya, K.; Kása, P.

In: Neurochemistry International, Vol. 6, No. 1, 1984, p. 123-126.

Research output: Contribution to journalArticle

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