Transport and transporters in the endoplasmic reticulum

Miklós Csala, Paola Marcolongo, Beáta Lizák, Silvia Senesi, Éva Margittai, Rosella Fulceri, Judit É Magyar, Angelo Benedetti, Gábor Bánhegyi

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Enzyme activities localized in the luminal compartment of the endoplasmic reticulum are integrated into the cellular metabolism by transmembrane fluxes of their substrates, products and/or cofactors. Most compounds involved are bulky, polar or even charged; hence, they cannot be expected to diffuse through lipid bilayers. Accordingly, transport processes investigated so far have been found protein-mediated. The selective and often rate-limiting transport processes greatly influence the activity, kinetic features and substrate specificity of the corresponding luminal enzymes. Therefore, the phenomenological characterization of endoplasmic reticulum transport contributes largely to the understanding of the metabolic functions of this organelle. Attempts to identify the transporter proteins have only been successful in a few cases, but recent development in molecular biology promises a better progress in this field.

Original languageEnglish
Pages (from-to)1325-1341
Number of pages17
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1768
Issue number6
DOIs
Publication statusPublished - Jun 1 2007

Keywords

  • Glucose 6-phosphate translocase
  • Nucleotide sugar transporters
  • Permeability
  • Solute carrier family 35
  • TAP
  • Translocon

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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