Transplantation of cultured embryonic spinal cord grafts into the hemisected spinal cord of adult rabbits

György T. Szeifert, Terézia Ladocsi, Anikó Zágon, László Fedina, Emil Pásztor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Spinal cord fragments from 20-day-old rabbit embryos cultivated for 1 week were transplanted into the hemisected and intact spinal cord of adult rabbits. The morphological changes at the site of intervention were investigated by light and electron microscopy 3, 12, and 29 weeks following implantation. In 80% of the animals the procedure was successful. The implants grew in volume, the cells matured, and many new neural processes with myelinization and synapse formation appeared. The histological findings indicate the survival, maturation, and integration of transplanted cultured embryonic spinal cord tissue in the lesioned adult spinal cord.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalSurgical Neurology
Volume32
Issue number4
DOIs
Publication statusPublished - Oct 1989

Keywords

  • Cultured embryonic tissue
  • Spinal cord
  • Transplantation

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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