Transplantable human non-Hodgkin lymphoma line in artificially immunesuppressed mice.

L. Kópper, P. Nagy, T. Revesz, J. Major, E. Magyarosy, K. Lapis

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2 Citations (Scopus)

Abstract

Diffuse non-Hodgkin lymphoma of B-cell origin has been established as a serially transplantable xenograft line in artificially immunesuppressed mice. The take rate and growth rate increased with repeated passages compared to the first transplant generation. However the xenografted tumor preserved many of its characteristics, including morphology, cell surface markers and DNA index. Chromosome analysis proved the human origin of tumors grown in mice and revealed translocation 8,14. Cyclophosphamide, Methotrexate and Vincristine produced substantial inhibition of tumor growth, while Dianhydrogalactitol and Adriamycin were less effective. Human alpha interferon also produced a delay in tumor growth.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalAnticancer Research
Volume7
Issue number2
Publication statusPublished - Mar 1987

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Non-Hodgkin's Lymphoma
Dianhydrogalactitol
Neoplasms
Growth
Vincristine
Genetic Markers
Heterografts
Interferon-alpha
Methotrexate
Doxorubicin
Cyclophosphamide
B-Lymphocytes
Chromosomes
Transplants

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Transplantable human non-Hodgkin lymphoma line in artificially immunesuppressed mice. / Kópper, L.; Nagy, P.; Revesz, T.; Major, J.; Magyarosy, E.; Lapis, K.

In: Anticancer Research, Vol. 7, No. 2, 03.1987, p. 193-198.

Research output: Contribution to journalArticle

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