Transneuronal retrograde viral labeling in the brain stem and hypothalamus is more intense from the left than from the right adrenal gland

Ida E. Tóth, Ory Wiesel, Dorina E. Tóth, Zsolt Boldogkoi, Béla Halász, Ida Gerendai

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Previous studies using the viral transneuronal tracing technique demonstrated central autonomic circuits involved in the innervation of the adrenal gland. Since increasing number of data indicate laterality in the neuroendocrine system, we aimed to investigate whether the supraspinal innervation of the adrenal gland exhibits asymmetry or not. The central circuitry involved in the innervation of the left and the right adrenal gland was studied in individual rats by dual transneuronal tracing using isogenic recombinant strains (Ba-DupGreen and Ba-Duplac expressing lacZ) of Bartha strain of pseudorabies virus. Viral infection of brain nuclei (dorsal vagal nucleus, nucleus of the solitary tract, caudal raphe nuclei, A5 cell group, hypothalamic paraventricular nucleus) from the left adrenal was more severe than that from the right organ. Dual-infected neurons were present both in the brain stem and in the hypothalamus. The results indicate a predominance in the supraspinal innervation of the left adrenal gland, and that each adrenal gland is innervated both by side-specific neurons and by neurons that project to both organs.

Original languageEnglish
Pages (from-to)503-509
Number of pages7
JournalMicroscopy Research and Technique
Volume71
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

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Keywords

  • Adrenal
  • Asymmetry
  • Dual viral tracing
  • Pseudorabies virus
  • Supraspinal innervation

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology

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