Arterial synthetic prostheses implanted in humans were investigated by transmission and scanning electron microscopy. The duration of implantation was from 15 months up to 8 years. The incorporation of the vascular prosthesis results in the development of a new vessel wall at the proximal end. The newly developed tissue is composed of a neointima, neomedia and a neoadventitia. The neointima consists of endothelial lining, the neomedia contains smooth muscle cells, elastic and collagen fibers and the neoadventitia is composed of connective tissue fibers. Neointima and neomedia formation in the central and distal part is minimal. No endothelialization occurs and the luminal surface is covered by fibrin, interspersed with loosely attached cells originating from the circulating blood. The preferential place for thrombus formation is the proximal end where the narrowing of the lumen by a bulky neointima provokes platelet adhesion. Though, in the central and distal part fibrin and collagen fibers are in direct contact with the blood flow, platelet aggregation and thrombus formation does not occur. Cells constituting the incorporation of the prosthesis may originate from the adjacent host arteries, from the external connective tissue and from the circulating blood.
|Number of pages||6|
|Journal||Vasa - Journal of Vascular Diseases|
|Publication status||Published - Dec 1 1980|
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine