Transmission and scanning-electromicroscopy of experimentasl liver metastases derived from intrasplenically growing primary tumor

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Liver metastasis formation from intrasplenically growing Lewis lung tumor studied with transmission and scanning electron microscopy. Tumor cells arrested in the sinusoids formed desmosome-like junctions with endothel cells and crossed the endothelial lining at intercellular gaps and by transcellular diapedesis. The metastatic foci had no newly formed vessels, and the stroma was provided by non-parenchymatous liver cells. Morphology suggested different outcome for tumor cell-host cell interactions at different stages of tumor growth. The host cell activity to destroy tumor cells was present only at the early stage but disappeared later, when the tumor cells were ready to phagocyte normal cells. The reason for this could be the immunesuppressive effect of the primary tumor. Results emphasize the importance to study metastasis formation in primary tumor-bearing hosts.

Original languageEnglish
Pages (from-to)47-59
Number of pages13
JournalPathology Research and Practice
Volume177
Issue number1
Publication statusPublished - 1983

Fingerprint

Neoplasm Metastasis
Liver
Neoplasms
Transendothelial and Transepithelial Migration
Desmosomes
Scanning Transmission Electron Microscopy
Phagocytes
Cell Communication
Endothelial Cells
Lung
Growth

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

@article{8f822663e0ab4846a844714871d3adef,
title = "Transmission and scanning-electromicroscopy of experimentasl liver metastases derived from intrasplenically growing primary tumor",
abstract = "Liver metastasis formation from intrasplenically growing Lewis lung tumor studied with transmission and scanning electron microscopy. Tumor cells arrested in the sinusoids formed desmosome-like junctions with endothel cells and crossed the endothelial lining at intercellular gaps and by transcellular diapedesis. The metastatic foci had no newly formed vessels, and the stroma was provided by non-parenchymatous liver cells. Morphology suggested different outcome for tumor cell-host cell interactions at different stages of tumor growth. The host cell activity to destroy tumor cells was present only at the early stage but disappeared later, when the tumor cells were ready to phagocyte normal cells. The reason for this could be the immunesuppressive effect of the primary tumor. Results emphasize the importance to study metastasis formation in primary tumor-bearing hosts.",
author = "J. T{\'i}m{\'a}r and L. K{\'o}pper and K. Pal and K. Lapis",
year = "1983",
language = "English",
volume = "177",
pages = "47--59",
journal = "Pathology Research and Practice",
issn = "0344-0338",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "1",

}

TY - JOUR

T1 - Transmission and scanning-electromicroscopy of experimentasl liver metastases derived from intrasplenically growing primary tumor

AU - Tímár, J.

AU - Kópper, L.

AU - Pal, K.

AU - Lapis, K.

PY - 1983

Y1 - 1983

N2 - Liver metastasis formation from intrasplenically growing Lewis lung tumor studied with transmission and scanning electron microscopy. Tumor cells arrested in the sinusoids formed desmosome-like junctions with endothel cells and crossed the endothelial lining at intercellular gaps and by transcellular diapedesis. The metastatic foci had no newly formed vessels, and the stroma was provided by non-parenchymatous liver cells. Morphology suggested different outcome for tumor cell-host cell interactions at different stages of tumor growth. The host cell activity to destroy tumor cells was present only at the early stage but disappeared later, when the tumor cells were ready to phagocyte normal cells. The reason for this could be the immunesuppressive effect of the primary tumor. Results emphasize the importance to study metastasis formation in primary tumor-bearing hosts.

AB - Liver metastasis formation from intrasplenically growing Lewis lung tumor studied with transmission and scanning electron microscopy. Tumor cells arrested in the sinusoids formed desmosome-like junctions with endothel cells and crossed the endothelial lining at intercellular gaps and by transcellular diapedesis. The metastatic foci had no newly formed vessels, and the stroma was provided by non-parenchymatous liver cells. Morphology suggested different outcome for tumor cell-host cell interactions at different stages of tumor growth. The host cell activity to destroy tumor cells was present only at the early stage but disappeared later, when the tumor cells were ready to phagocyte normal cells. The reason for this could be the immunesuppressive effect of the primary tumor. Results emphasize the importance to study metastasis formation in primary tumor-bearing hosts.

UR - http://www.scopus.com/inward/record.url?scp=0020972448&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020972448&partnerID=8YFLogxK

M3 - Article

VL - 177

SP - 47

EP - 59

JO - Pathology Research and Practice

JF - Pathology Research and Practice

SN - 0344-0338

IS - 1

ER -