Transzmetilezési folyamatok és a redox-homeosztázis

Translated title of the contribution: Transmethylation and the redox homeostasis

Dénes Kleiner, András Bersényi, H. Fébel, Viktor Hegedus, Eszter Mátis, Éva Sárdi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Transmethylation modifies configuration and proceeds via formaldehyde. It has a significant role for example in epigenetic regulation. The whole methyl-pool can be evaluated by the measurement of bound formaldehyde. Aim: The bound formaldehyde was measured in wheat, bean, beetroot, cabbage, broiler-and rabbit liver. The relationship between transmethylation and redox homeosthasis was studied in the liver of domestic animals, and in the rat model of fatty liver. Method: The diet of rats was enriched with cholesterol, sunflower oil and cholic acid. The bound formaldehyde was determined by overpressured layer chromatography. The hydrogen-donating ability was measured with 1.1-diphenyl-2-picrylhydrazylt free radical using spectrophotometric measurement. Results: Beans had the most bound formaldehyde. The liver of broilers possessed significantly elevated hydrogen-donating ability and transmethylation ability. Rats with severe fatty liver had significantly less bound formaldehyde and the hydrogen-donating ability tendentiously decreased. Conclusions: These results draw attention to the diet, especially in obesity and obesity-related diseases.

Original languageHungarian
Pages (from-to)1180-1187
Number of pages8
JournalOrvosi Hetilap
Volume154
Issue number30
DOIs
Publication statusPublished - Jul 1 2013

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Formaldehyde
Oxidation-Reduction
Homeostasis
Hydrogen
Fatty Liver
Liver
Obesity
Diet
Cholic Acid
Brassica
Domestic Animals
Epigenomics
Triticum
Free Radicals
Chromatography
Cholesterol
Rabbits

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kleiner, D., Bersényi, A., Fébel, H., Hegedus, V., Mátis, E., & Sárdi, É. (2013). Transzmetilezési folyamatok és a redox-homeosztázis. Orvosi Hetilap, 154(30), 1180-1187. https://doi.org/10.1556/OH.2013.29623

Transzmetilezési folyamatok és a redox-homeosztázis. / Kleiner, Dénes; Bersényi, András; Fébel, H.; Hegedus, Viktor; Mátis, Eszter; Sárdi, Éva.

In: Orvosi Hetilap, Vol. 154, No. 30, 01.07.2013, p. 1180-1187.

Research output: Contribution to journalArticle

Kleiner, D, Bersényi, A, Fébel, H, Hegedus, V, Mátis, E & Sárdi, É 2013, 'Transzmetilezési folyamatok és a redox-homeosztázis', Orvosi Hetilap, vol. 154, no. 30, pp. 1180-1187. https://doi.org/10.1556/OH.2013.29623
Kleiner D, Bersényi A, Fébel H, Hegedus V, Mátis E, Sárdi É. Transzmetilezési folyamatok és a redox-homeosztázis. Orvosi Hetilap. 2013 Jul 1;154(30):1180-1187. https://doi.org/10.1556/OH.2013.29623
Kleiner, Dénes ; Bersényi, András ; Fébel, H. ; Hegedus, Viktor ; Mátis, Eszter ; Sárdi, Éva. / Transzmetilezési folyamatok és a redox-homeosztázis. In: Orvosi Hetilap. 2013 ; Vol. 154, No. 30. pp. 1180-1187.
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