Transition metal complexes of two new imino-dihydroxamic acids

M. Amélia Santos, Raquel Grazina, Margarida Pinto, E. Farkas

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Two new iminodihydroxamic acids [N-benzyl-iminobis(propionohydroxamic acid) and N-benzyl-iminobis(butyrohydroxamic acid)] were prepared and studied as specific binders for the transition M2+ ions due to their potential interest as inhibitors of metalloproteinases. Their architecture is based on aliphatic backbones, as spacers connecting two hydroxamate chelating units, with an N-benzyl group inserted in that skeleton to simulate the protein lipophilic subset. Herein, we first report the synthetic procedure that basically involves the formation of the corresponding intermediates with two nitrile groups, which were then converted to the CONHOH moieties. Then, the acid-base and the chelating properties of these ligands towards Cu2+, Ni2+ and Zn2+ ions, studied by potentiometric and spectrophotometric techniques, are described. Both the ligands form quite stable complexes with these metal ions, presenting a preferential M2+ coordination to the hydroxamate over the amine groups, according to the order Zn2+ ≥ Ni2+ > Cu2+.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalInorganica Chimica Acta
Volume321
Issue number1-2
DOIs
Publication statusPublished - Sep 10 2001

Fingerprint

Imino Acids
Coordination Complexes
Metal complexes
Transition metals
transition metals
Ions
Chelation
acids
Acids
Ligands
Nitriles
Metalloproteases
Skeleton
ligands
Amines
Binders
Metal ions
nitriles
musculoskeletal system
inhibitors

Keywords

  • Amino-dihydroxamate
  • Copper-hydroxamate
  • Hydroxamic acid
  • Nickel-hydroxamate
  • Zinc-hydroxamate

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Physical and Theoretical Chemistry
  • Materials Chemistry

Cite this

Transition metal complexes of two new imino-dihydroxamic acids. / Amélia Santos, M.; Grazina, Raquel; Pinto, Margarida; Farkas, E.

In: Inorganica Chimica Acta, Vol. 321, No. 1-2, 10.09.2001, p. 42-48.

Research output: Contribution to journalArticle

Amélia Santos, M. ; Grazina, Raquel ; Pinto, Margarida ; Farkas, E. / Transition metal complexes of two new imino-dihydroxamic acids. In: Inorganica Chimica Acta. 2001 ; Vol. 321, No. 1-2. pp. 42-48.
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