Transition metal complexes of amino acids and derivatives containing disulphide bridges

Katalin Várnagy, Imre Sóvágó, Henryk Kozłowski

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The interaction of cobalt(II), nickel(II), copper(II) and zinc(II) with D-penicillamine disulphide, oxidized glutathione and L-cysteinylglycine disulphide were studied by pH-metric, spectrophotometric and EPR methods. D-Penicillamine disulphide forms binuclear complexes with all the metal ions studied. The formation of 1:1 complexes is characteristic of oxidized glutathione. L-Cysteinylglycine disulphide behaves like dipeptides, but the presence of two separate peptide moieties also results in the formation of various binuclear complexes. Metal ion-disulphide binding was not observed in any case.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalInorganica Chimica Acta
Issue number2
Publication statusPublished - Feb 1988


ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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