Transient receptor potential vanilloid-1 signaling inhibits differentiation and activation of human dendritic cells

Balázs I. Tóth, Szilvia Benko, Attila G. Szöllosi, László Kovács, Éva Rajnavölgyi, Tamás Bíró

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The goal of the current study was to investigate the expression of transient receptor potential vanilloid-1 (TRPV1) on human in vitro differentiated monocyte-derived dendritic cells (DCs) and to dissect the corresponding role of TRPV1-signaling in DC-specific functions. TRPV1 expression was identified both at the protein and gene levels in human DCs. Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. These data introduce TRPV1-coupled signaling as a novel player in human monocyte-derived DC biology with anti-inflammatory actions.

Original languageEnglish
Pages (from-to)1619-1624
Number of pages6
JournalFEBS letters
Volume583
Issue number10
DOIs
Publication statusPublished - May 19 2009

    Fingerprint

Keywords

  • Anti-inflammatory
  • Cytokine release
  • Differentiation
  • Human dendritic cell
  • Transient receptor potential vanilloid-1

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this