Transient receptor potential channels as therapeutic targets

Magdalene M. Moran, Michael Allen McAlexander, T. Bíró, Arpad Szallasi

Research output: Contribution to journalArticle

341 Citations (Scopus)

Abstract

Transient receptor potential (TRP) cation channels have been among the most aggressively pursued drug targets over the past few years. Although the initial focus of research was on TRP channels that are expressed by nociceptors, there has been an upsurge in the amount of research that implicates TRP channels in other areas of physiology and pathophysiology, including the skin, bladder and pulmonary systems. In addition, mutations in genes encoding TRP channels are the cause of several inherited diseases that affect a variety of systems including the renal, skeletal and nervous system. This Review focuses on recent developments in the TRP channel-related field, and highlights potential opportunities for therapeutic intervention.

Original languageEnglish
Pages (from-to)601-620
Number of pages20
JournalNature Reviews Drug Discovery
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 2011

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Transient Receptor Potential Channels
Therapeutics
Nociceptors
Research
Nervous System
Urinary Bladder
Kidney
Lung
Skin
Mutation
Pharmaceutical Preparations
Genes

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Transient receptor potential channels as therapeutic targets. / Moran, Magdalene M.; McAlexander, Michael Allen; Bíró, T.; Szallasi, Arpad.

In: Nature Reviews Drug Discovery, Vol. 10, No. 8, 08.2011, p. 601-620.

Research output: Contribution to journalArticle

Moran, Magdalene M. ; McAlexander, Michael Allen ; Bíró, T. ; Szallasi, Arpad. / Transient receptor potential channels as therapeutic targets. In: Nature Reviews Drug Discovery. 2011 ; Vol. 10, No. 8. pp. 601-620.
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