Transient receptor potential channels and itch

How deep should we scratch?

Balázs I. Tóth, Balázs I. Tóth, Arpad Szallasi, T. Bíró

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Over the past 30 years, transient receptor potential (TRP) channels have evolved from a somewhat obscure observation on how fruit flies detect light to become the center of drug discovery efforts, triggering a heated debate about their potential as targets for therapeutic applications in humans. In this review, we describe our current understanding of the diverse mechanism of action of TRP channels in the itch pathway from the skin to the brain with focus on the peripheral detection of stimuli that elicit the desire to scratch and spinal itch processing and sensitization. We predict that the compelling basic research findings on TRP channels and pruritus will be translated into the development of novel, clinically useful itch medications.

Original languageEnglish
Pages (from-to)89-133
Number of pages45
JournalHandbook of Experimental Pharmacology
Volume226
DOIs
Publication statusPublished - 2015

Fingerprint

Transient Receptor Potential Channels
Drug Discovery
Pruritus
Fruits
Diptera
Fruit
Brain
Skin
Light
Processing
Research
Therapeutics

Keywords

  • Capsaicin
  • Menthol
  • Pruriceptive sensory fibers
  • Pruritic TRP channels
  • Spinal itch processing
  • TRPA1
  • TRPM8
  • TRPV1
  • TRPV3

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Biochemistry
  • Medicine(all)

Cite this

Transient receptor potential channels and itch : How deep should we scratch? / Tóth, Balázs I.; Tóth, Balázs I.; Szallasi, Arpad; Bíró, T.

In: Handbook of Experimental Pharmacology, Vol. 226, 2015, p. 89-133.

Research output: Contribution to journalArticle

Tóth, Balázs I. ; Tóth, Balázs I. ; Szallasi, Arpad ; Bíró, T. / Transient receptor potential channels and itch : How deep should we scratch?. In: Handbook of Experimental Pharmacology. 2015 ; Vol. 226. pp. 89-133.
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