Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia: The effects of dichloroacetate (DCA)

A. Aynsley-Green, A. M. Weindling, G. Soltész, P. A. Jenkins

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Soon after birth a 36-weekgestational age, appropriate for dates, newborn infant developed hyperinsulinaemic hypoglycaemia which responded to diazoxide and glucose infusion. While normoglycaemic, he became increasingly ill with high lactate, pyruvate, and alanine levels. Provocation tests suggested a defect in lactate handling. Dichloroacetate (DCA) was given and resulted in the prompt normalisation of his metabolic profile with no recurrence after discontinuation of the drug. A second episode of hyperinsulinaemic hypoglycaemia followed and this was controlled satisfactorily by short term diazoxide treatment. Diazoxide treatment could be stopped at the age of 1 month. Although at the age of 1.5 years the infant is retarded developmentally, there has been no recurrence of lactic acidosis nor hyperinsulinaemic hypoglycaemia. The association of lactic acidosis and hyperinsulinism, and the use of DCA in this circumstance have not been reported previously.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalEuropean Journal of Pediatrics
Volume141
Issue number2
DOIs
Publication statusPublished - Dec 1983

Fingerprint

Diazoxide
Lactic Acidosis
Hypoglycemia
Lactic Acid
Recurrence
Metabolome
Hyperinsulinism
Pyruvic Acid
Alanine
Parturition
Newborn Infant
Glucose
Therapeutics
Pharmaceutical Preparations
Hyper-Beta-Alaninemia

Keywords

  • Dichloroacetate
  • Hyperinsulinaemic hypoglycaemia
  • Transient lactic acidaemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Transient lactic acidosis and hyperalaninaemia associated with neonatal hyperinsulinaemic hypoglycaemia : The effects of dichloroacetate (DCA). / Aynsley-Green, A.; Weindling, A. M.; Soltész, G.; Jenkins, P. A.

In: European Journal of Pediatrics, Vol. 141, No. 2, 12.1983, p. 114-117.

Research output: Contribution to journalArticle

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