Transient induction of fatty acid synthase in rat liver after removal of a peroxisome proliferator

Kiyoto Motojima, Masanori Isaka, Yasuko Takino, Sataro Goto

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Removal of a peroxisome proliferator from the diet triggered the degradation of peroxisomes and induced the transient expression of a 220 kDa soluble protein in rat liver. The 220 kDa protein was purified by conventional methods and analyzed by amino acid sequencing. A total of 99 amino acid residues in 4 lysylendopeptidase-digested peptides completely matched those in rat fatty acid synthase. The transient induction of fatty acid synthase mRNA during peroxisome degradation was confirmed by Northern blotting.

Original languageEnglish
Pages (from-to)122-124
Number of pages3
JournalFEBS letters
Volume356
Issue number1
DOIs
Publication statusPublished - Dec 14 1994

Keywords

  • Fatty acid synthase
  • PPAR
  • Peroxisome
  • Peroxisome proliferator
  • Rat liver

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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