Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats

Csongor S. Ábrahám, Noboru Harada, Mária A. Deli, Masami Niwa

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1. The aim of the present study was to reveal the effect of transient forebrain ischemia on the regional and temporal changes in the permeability of the blood-brain barrier (BBB) permeability for sodium fluorescein (MW: 376 Da) and Evan's blue-labeled albumin (MW: 67 kDa) in stroke-prone spontaneously hypertensive rats (SHRSP). 2. BBB permeability was significantly higher in the brain regions of 16-week-old control SHRSP than those in age-matched normotensive Wistar-Kyoto rats. 3. Transient forebrain ischemia evoked by 10-min bilateral carotid occlusion increased the permeability of the BBB for albumin, but not for sodium fluorescein, after 6 and 24 h of reperfusion in brain regions of SHRSP. 4. Extravasation of serum macromolecules may contribute to neuronal loss and development of hypertensive encephalopathy in SHRSP.

Original languageEnglish
Pages (from-to)455-462
Number of pages8
JournalCellular and Molecular Neurobiology
Issue number4
Publication statusPublished - Aug 1 2002



  • Blood-brain barrier permeability
  • Cerebral ischemia-reperfusion
  • Evan's blue-albumin
  • Sodium fluorescein
  • Stroke-prone spontaneously hypertensive rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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