Transglutaminase 2 in the balance of cell death and survival

Research output: Contribution to journalArticle

147 Citations (Scopus)

Abstract

Transglutaminase 2 (TG2), a multifunctional enzyme with Ca 2+-dependent protein crosslinking activity and GTP-dependent G protein functions, is often upregulated in cells undergoing apoptosis. In cultured cells TG2 may exert both pro- and anti-apoptotic effects depending upon the type of cell, the kind of death stimuli, the intracellular localization of the enzyme and the type of its activities switched on. The majority of data support the notion that transamidation by TG2 can both facilitate and inhibit apoptosis, while the GTP-bound form of the enzyme generally protects cells against death. In vivo studies confirm the Janus face of TG2 in the initiation of the apoptotic program. In addition, they reveal a further role: the prevention of inflammation, tissue injury and autoimmunity once the apoptosis has already been initiated. This function of TG2 is partially achieved by being expressed and activated also in macrophages digesting apoptotic cells and mediating a crosstalk between dying and phagocytic cells.

Original languageEnglish
Pages (from-to)3297-3302
Number of pages6
JournalFEBS Letters
Volume579
Issue number15
DOIs
Publication statusPublished - Jun 13 2005

Fingerprint

Cell death
Cell Survival
Cell Death
Apoptosis
Guanosine Triphosphate
Multifunctional Enzymes
Cells
Macrophages
Enzymes
Phagocytes
Crosstalk
Autoimmunity
GTP-Binding Proteins
Crosslinking
Cultured Cells
transglutaminase 2
Tissue
Inflammation
Wounds and Injuries
Proteins

Keywords

  • Apoptosis
  • Autoimmunity
  • Phagocytosis
  • Signalling pathway
  • Transglutaminase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Transglutaminase 2 in the balance of cell death and survival. / Fésüs, L.; Szondy, Z.

In: FEBS Letters, Vol. 579, No. 15, 13.06.2005, p. 3297-3302.

Research output: Contribution to journalArticle

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