Transglutaminase 2 in human diseases

Z. Szondy, Ilma Korponay-Szabó, Robert Király, Z. Sarang, Gregory J. Tsay

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co-receptor for integrin β1 and β3 integrins distinguishing it from other members of the transglutaminase family. TG2 is ubiquitously expressed in almost all cell types and all cell compartments, and is also present on the cell surface and gets secreted to the extracellular matrix via non-classical mechanisms. TG2 has been associated with various human diseases including inflammation, cancer, fibrosis, cardiovascular disease, neurodegenerative diseases, celiac disease in which it plays either a protective role, or contributes to the pathogenesis. Thus modulating the biological activities of TG2 in these diseases will have a therapeutic value.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalBioMedicine (France)
Volume7
Issue number3
DOIs
Publication statusPublished - Sep 1 2017

Fingerprint

Integrins
Neurodegenerative diseases
Acyltransferases
Transglutaminases
Celiac Disease
Bioactivity
GTP-Binding Proteins
Neurodegenerative Diseases
Extracellular Matrix
Fibrosis
Cardiovascular Diseases
transglutaminase 2
Inflammation
Enzymes
Neoplasms
Proteins
Therapeutics

Keywords

  • Cancer
  • Cardiovascular Disease
  • Celiac Disease
  • Fibrosis
  • Inflammation
  • Neurodegenerative Disease
  • Transglutaminase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Transglutaminase 2 in human diseases. / Szondy, Z.; Korponay-Szabó, Ilma; Király, Robert; Sarang, Z.; Tsay, Gregory J.

In: BioMedicine (France), Vol. 7, No. 3, 01.09.2017, p. 1-13.

Research output: Contribution to journalReview article

Szondy, Z, Korponay-Szabó, I, Király, R, Sarang, Z & Tsay, GJ 2017, 'Transglutaminase 2 in human diseases', BioMedicine (France), vol. 7, no. 3, pp. 1-13. https://doi.org/10.1051/bmdcn/2017070315
Szondy, Z. ; Korponay-Szabó, Ilma ; Király, Robert ; Sarang, Z. ; Tsay, Gregory J. / Transglutaminase 2 in human diseases. In: BioMedicine (France). 2017 ; Vol. 7, No. 3. pp. 1-13.
@article{97953594588344b0a00066846d7615bd,
title = "Transglutaminase 2 in human diseases",
abstract = "Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co-receptor for integrin β1 and β3 integrins distinguishing it from other members of the transglutaminase family. TG2 is ubiquitously expressed in almost all cell types and all cell compartments, and is also present on the cell surface and gets secreted to the extracellular matrix via non-classical mechanisms. TG2 has been associated with various human diseases including inflammation, cancer, fibrosis, cardiovascular disease, neurodegenerative diseases, celiac disease in which it plays either a protective role, or contributes to the pathogenesis. Thus modulating the biological activities of TG2 in these diseases will have a therapeutic value.",
keywords = "Cancer, Cardiovascular Disease, Celiac Disease, Fibrosis, Inflammation, Neurodegenerative Disease, Transglutaminase",
author = "Z. Szondy and Ilma Korponay-Szab{\'o} and Robert Kir{\'a}ly and Z. Sarang and Tsay, {Gregory J.}",
year = "2017",
month = "9",
day = "1",
doi = "10.1051/bmdcn/2017070315",
language = "English",
volume = "7",
pages = "1--13",
journal = "BioMedicine (Netherlands)",
issn = "2211-8020",
publisher = "Elsevier BV",
number = "3",

}

TY - JOUR

T1 - Transglutaminase 2 in human diseases

AU - Szondy, Z.

AU - Korponay-Szabó, Ilma

AU - Király, Robert

AU - Sarang, Z.

AU - Tsay, Gregory J.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co-receptor for integrin β1 and β3 integrins distinguishing it from other members of the transglutaminase family. TG2 is ubiquitously expressed in almost all cell types and all cell compartments, and is also present on the cell surface and gets secreted to the extracellular matrix via non-classical mechanisms. TG2 has been associated with various human diseases including inflammation, cancer, fibrosis, cardiovascular disease, neurodegenerative diseases, celiac disease in which it plays either a protective role, or contributes to the pathogenesis. Thus modulating the biological activities of TG2 in these diseases will have a therapeutic value.

AB - Transglutaminase 2 (TG2) is an inducible transamidating acyltransferase that catalyzes Ca(2+)-dependent protein modifications. In addition to being an enzyme, TG2 also serves as a G protein for several seven transmembrane receptors and acts as a co-receptor for integrin β1 and β3 integrins distinguishing it from other members of the transglutaminase family. TG2 is ubiquitously expressed in almost all cell types and all cell compartments, and is also present on the cell surface and gets secreted to the extracellular matrix via non-classical mechanisms. TG2 has been associated with various human diseases including inflammation, cancer, fibrosis, cardiovascular disease, neurodegenerative diseases, celiac disease in which it plays either a protective role, or contributes to the pathogenesis. Thus modulating the biological activities of TG2 in these diseases will have a therapeutic value.

KW - Cancer

KW - Cardiovascular Disease

KW - Celiac Disease

KW - Fibrosis

KW - Inflammation

KW - Neurodegenerative Disease

KW - Transglutaminase

UR - http://www.scopus.com/inward/record.url?scp=85038607325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85038607325&partnerID=8YFLogxK

U2 - 10.1051/bmdcn/2017070315

DO - 10.1051/bmdcn/2017070315

M3 - Review article

AN - SCOPUS:85038607325

VL - 7

SP - 1

EP - 13

JO - BioMedicine (Netherlands)

JF - BioMedicine (Netherlands)

SN - 2211-8020

IS - 3

ER -