Transgenerational Effects of Perinatal Hormonal Imprinting

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

Perinatal hormonal imprinting is a physiological process that is needed for the completion of hormone receptor maturation. However, in this critical period of development the receptors are not able to discriminate the real target molecules from related ones, so hormone analogs, related hormones, drugs, and environmental contaminants, such as endocrine disruptors, provoke faulty imprinting with life-long biochemical and functional consequences. The epigenetic effects of hormonal imprinting are inherited from cell to cell and from organism to organism. As the imprinting is not age-dependent but depends on the developmental state, late imprinting (mainly in continuously differentiating cell lines) also occurs. The main source of late imprinting is the pollution of air, food, and water, alongside medicinal imprinting, all of which are transgenerationally transmitted. The present and future consequences are discussed.

Original languageEnglish
Title of host publicationTransgenerational Epigenetics
PublisherElsevier Inc.
Pages255-267
Number of pages13
ISBN (Print)9780124059443
DOIs
Publication statusPublished - May 2014

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Keywords

  • Development
  • Endocrine disruptors
  • Epigenetics
  • Faulty imprinting
  • Hereditary transmission
  • Hormonal imprinting
  • Hormone receptors
  • Neonatal treatment

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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