Transgenerational effect of neonatal vitamin A or D treatment (hormonal imprinting) on the hormone content of rat immune cells

G. Csaba, P. Kovács, É Pállinger

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Male offspring of neonatally vitamin A or D treated (hormonally imprinted) rat dams were studied for hormone (adrenocorticotrophine [ACTH], β-endorphin, histamine, triiodothyronine [T3]) content in immune cells, by using immunocytochemical methods for flow cytometry and confocal microscopy. ACTH and T3 were almost doubled in the lymphocytes of vitamin A treated mothers' offspring, while histamine decreased to a one-third in the histamine content of vitamin D treated mothers' offspring. Part of the animals received vitamin treatment again 24 hours before measurement, however, only endorphin content elevated moderately. In the offspring of untreated dams administered with vitamin D 24 hours before measurement, each cell type studied (lymphocyte, monocyte-granulocyte group, mast cell) had a one-third lower T 3 content, which shows that vitamin D treatment can influence hormone content of immune cells. The experiments call attention to the transgenerational effect of perinatal treatment with lipid-soluble, intracellular receptor-bound vitamins.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalHormone and Metabolic Research
Volume39
Issue number3
DOIs
Publication statusPublished - Mar 1 2007

Keywords

  • ACTH
  • Histamine
  • Imprinting
  • Inheritance
  • Perinatal effect
  • Triiodothyronine
  • Vitamins
  • White blood cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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