Transganglionic regulation of central terminals of dorsal root ganglion cells by nerve growth factor (NGF)

Bert Csillik, Martin E. Schwab, Hans Thoenen

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Blockade of axonal transport or transection of the rat sciatic nerve results in transganglionic degenerative atrophy (TDA) of nerve terminals containing fluoride-resistant acid phosphatase (FRAP) in the Rolando substance of the spinal cord. Application of vinblastine (9 μg) in a cuff around the sciatic nerve of adult rats blocked the retrograde transport of [125I]NGF in sensory fibers; this amount of vinblastine is identical to the threshold amount that induces TDA. Conversely, application of NGF to the proximal stump of the transected sciatic nerve prevented or delayed the occurrence of TDA as reflected by the maintenance of FRAP in the upper dorsal horn, that otherwise would inevitably disappear following the peripheral nerve lesion. These results suggest that endogenous NGF transported retrogradely in peripheral sensory fibers of the adult rat under normal conditions may be responsible for the regulation of the structural and functional integrity of the central terminals of these FRAP-containing primary sensory neurons and that TDA may be the consequence of the failure of NGF to reach the perikarya of these neurons.

Original languageEnglish
Pages (from-to)11-15
Number of pages5
JournalBrain research
Volume331
Issue number1
DOIs
Publication statusPublished - Apr 1 1985

Keywords

  • axoplasmic transport
  • degeneration
  • dorsal root ganglion
  • nerve growth factor
  • spinal cord

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Transganglionic regulation of central terminals of dorsal root ganglion cells by nerve growth factor (NGF)'. Together they form a unique fingerprint.

  • Cite this