Transformation of hamster embryonic fibroblast cells by UV-irradiated human cytomegalovirus.

I. Boldogh, E. Gönczöl, L. Váczi

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Infection of hamster embryonic fibroblast (HEF) cells with UV-irradiated human CMV resulted in appearance of transformed clones. The established cell line (87-TRH-5) when inoculated subcutaneously induced tumour in newborn hamsters. The 87-TRH-5 cell line and the cell lines (87-TRH-5-Tsc1, 87-TRH-5-Tsc2, 87TRH-5-Tsc3) developed from the induced tumour, proved to bear CMV-spcific cytoplasmic and surface antigens. Demonstration of infectious CMV or MCV-specific nuclear antigen in 87-THR-5-cells has failed.

Original languageEnglish
Pages (from-to)269-275
Number of pages7
JournalActa microbiologica Academiae Scientiarum Hungaricae
Issue number4
Publication statusPublished - Dec 1 1978


ASJC Scopus subject areas

  • Medicine(all)

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