trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk: Results of a large birth cohort study

Éva Szabó, Günther Boehm, Christopher Beermann, Maria Weyermann, Hermann Brenner, Dietrich Rothenbacher, T. Decsi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: Several observational studies indicate that trans isomeric fatty acids may interfere with the metabolism of essential fatty acids in the human organism. Objective: The objective was to investigate the relation between trans fatty acids and long-chain polyunsaturates in mature human milk. Design: Human milk samples (n = 769) were obtained at the 6th week of lactation from mothers participating in a birth cohort study in Germany. The fatty acid composition of the milk samples was measured by high-resolution capillary gas-liquid chromatography. Results: trans Octadecenoic and trans octadecadienoic acids were inversely correlated with linoleic acid (r = -0.32 and -0.33, P <0.0001 for both), α-linolenic acid (r = -0.35 and -0.27, P <0.0001), arachidonic acid (r = -0.60 and -0.47, P <0.0001), and docosahexaenoic acid (r = -0.51 and -0.33, P <0.0001). In contrast, no inverse correlations were observed between trans hexadecenoic acid and polyunsaturated fatty acids. Conclusions: The data obtained in the present study suggest that the availability of 18-carbon trans isomeric fatty acids may be inversely related to the availability of long-chain polyunsaturated fatty acids in mature human milk.

Original languageEnglish
Pages (from-to)1320-1326
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume85
Issue number5
Publication statusPublished - May 1 2007

Fingerprint

Trans Fatty Acids
trans fatty acids
Human Milk
breast milk
cohort studies
Cohort Studies
Parturition
Unsaturated Fatty Acids
acids
Essential Fatty Acids
alpha-Linolenic Acid
long chain polyunsaturated fatty acids
Docosahexaenoic Acids
essential fatty acids
observational studies
Linoleic Acid
linolenic acid
docosahexaenoic acid
arachidonic acid
Lactation

Keywords

  • Arachidonic acid
  • Docosahexaenoic acid
  • Essential fatty acids
  • Long-chain polyunsaturated fatty acids
  • trans fatty acids

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk : Results of a large birth cohort study. / Szabó, Éva; Boehm, Günther; Beermann, Christopher; Weyermann, Maria; Brenner, Hermann; Rothenbacher, Dietrich; Decsi, T.

In: American Journal of Clinical Nutrition, Vol. 85, No. 5, 01.05.2007, p. 1320-1326.

Research output: Contribution to journalArticle

Szabó, Éva ; Boehm, Günther ; Beermann, Christopher ; Weyermann, Maria ; Brenner, Hermann ; Rothenbacher, Dietrich ; Decsi, T. / trans Octadecenoic acid and trans octadecadienoic acid are inversely related to long-chain polyunsaturates in human milk : Results of a large birth cohort study. In: American Journal of Clinical Nutrition. 2007 ; Vol. 85, No. 5. pp. 1320-1326.
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abstract = "Background: Several observational studies indicate that trans isomeric fatty acids may interfere with the metabolism of essential fatty acids in the human organism. Objective: The objective was to investigate the relation between trans fatty acids and long-chain polyunsaturates in mature human milk. Design: Human milk samples (n = 769) were obtained at the 6th week of lactation from mothers participating in a birth cohort study in Germany. The fatty acid composition of the milk samples was measured by high-resolution capillary gas-liquid chromatography. Results: trans Octadecenoic and trans octadecadienoic acids were inversely correlated with linoleic acid (r = -0.32 and -0.33, P <0.0001 for both), α-linolenic acid (r = -0.35 and -0.27, P <0.0001), arachidonic acid (r = -0.60 and -0.47, P <0.0001), and docosahexaenoic acid (r = -0.51 and -0.33, P <0.0001). In contrast, no inverse correlations were observed between trans hexadecenoic acid and polyunsaturated fatty acids. Conclusions: The data obtained in the present study suggest that the availability of 18-carbon trans isomeric fatty acids may be inversely related to the availability of long-chain polyunsaturated fatty acids in mature human milk.",
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AU - Szabó, Éva

AU - Boehm, Günther

AU - Beermann, Christopher

AU - Weyermann, Maria

AU - Brenner, Hermann

AU - Rothenbacher, Dietrich

AU - Decsi, T.

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N2 - Background: Several observational studies indicate that trans isomeric fatty acids may interfere with the metabolism of essential fatty acids in the human organism. Objective: The objective was to investigate the relation between trans fatty acids and long-chain polyunsaturates in mature human milk. Design: Human milk samples (n = 769) were obtained at the 6th week of lactation from mothers participating in a birth cohort study in Germany. The fatty acid composition of the milk samples was measured by high-resolution capillary gas-liquid chromatography. Results: trans Octadecenoic and trans octadecadienoic acids were inversely correlated with linoleic acid (r = -0.32 and -0.33, P <0.0001 for both), α-linolenic acid (r = -0.35 and -0.27, P <0.0001), arachidonic acid (r = -0.60 and -0.47, P <0.0001), and docosahexaenoic acid (r = -0.51 and -0.33, P <0.0001). In contrast, no inverse correlations were observed between trans hexadecenoic acid and polyunsaturated fatty acids. Conclusions: The data obtained in the present study suggest that the availability of 18-carbon trans isomeric fatty acids may be inversely related to the availability of long-chain polyunsaturated fatty acids in mature human milk.

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