Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids

T. Decsi, Günther Boehm, H. M Ria Tjoonk, Szilárd Molnár, D. A. Janneke Dijck-Brouwer, Mijna Hadders-Algra, Ingrid A. Martini, Frits A J Muskiet, E. Rudy Boersma

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Abstract

Long-chain PUFA play an important role in early human neurodevelopment. Significant inverse correlations were reported between values of trans isomeric and long-chain PUFA in plasma lipids of preterm infants and children aged 1-15 yr as well as in venous cord blood lipids of full-term infants. Here we report FA compositional data of cord blood vessel wall lipids in 308 healthy, full-term infants (gestational age: 39.7 ± 1.2 wk, birth weight: 3528 ± 429 g, mean ± SD). The median (interquartile range) of the sum of 18-carbon trans FA was 0.22 (0.13) % w/w in umbilical artery and 0.16 (0.10) % w/w in umbilical vein lipids. Nonparametric correlation analysis showed significant inverse correlations between the sum of 18-carbon trans FA and both arachidonic acid and DHA in artery (r = -0.38, P <0.01, and r = -0.20, P <0.01) and vein (r = -0.36, P <0.01, and -0.17, P <0.01) wall lipids. In addition, the sum of 18-carbon trans FA was significantly positively correlated to Mead acid, a general indicator of EFA deficiency, in both artery (r= +0.35, P <0.01) and vein (r = +0.31, P <0.01) wall lipids. The present results obtained in a large group of full-term infants suggest that maternal trans FA intake is inversely associated with long-chain PUFA status of the infant at birth.

Original languageEnglish
Pages (from-to)959-965
Number of pages7
JournalLipids
Volume37
Issue number10
DOIs
Publication statusPublished - Oct 1 2002

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Oleic Acids
umbilicus
Umbilicus
arachidonic acid
Arachidonic Acid
Lipids
acids
lipids
blood lipids
arteries
carbon
Carbon
umbilical arteries
Fetal Blood
umbilical veins
neurodevelopment
gestational age
Veins
Arteries
blood vessels

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science
  • Biochemistry

Cite this

Decsi, T., Boehm, G., Tjoonk, H. M. R., Molnár, S., Janneke Dijck-Brouwer, D. A., Hadders-Algra, M., ... Boersma, E. R. (2002). Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids. Lipids, 37(10), 959-965. https://doi.org/10.1007/s11745-006-0987-y

Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids. / Decsi, T.; Boehm, Günther; Tjoonk, H. M Ria; Molnár, Szilárd; Janneke Dijck-Brouwer, D. A.; Hadders-Algra, Mijna; Martini, Ingrid A.; Muskiet, Frits A J; Boersma, E. Rudy.

In: Lipids, Vol. 37, No. 10, 01.10.2002, p. 959-965.

Research output: Contribution to journalArticle

Decsi, T, Boehm, G, Tjoonk, HMR, Molnár, S, Janneke Dijck-Brouwer, DA, Hadders-Algra, M, Martini, IA, Muskiet, FAJ & Boersma, ER 2002, 'Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids', Lipids, vol. 37, no. 10, pp. 959-965. https://doi.org/10.1007/s11745-006-0987-y
Decsi, T. ; Boehm, Günther ; Tjoonk, H. M Ria ; Molnár, Szilárd ; Janneke Dijck-Brouwer, D. A. ; Hadders-Algra, Mijna ; Martini, Ingrid A. ; Muskiet, Frits A J ; Boersma, E. Rudy. / Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids. In: Lipids. 2002 ; Vol. 37, No. 10. pp. 959-965.
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T1 - Trans isomeric octadecenoic acids are related inversely to arachidonic acid and DHA and positively related to mead acid in umbilical vessel wall lipids

AU - Decsi, T.

AU - Boehm, Günther

AU - Tjoonk, H. M Ria

AU - Molnár, Szilárd

AU - Janneke Dijck-Brouwer, D. A.

AU - Hadders-Algra, Mijna

AU - Martini, Ingrid A.

AU - Muskiet, Frits A J

AU - Boersma, E. Rudy

PY - 2002/10/1

Y1 - 2002/10/1

N2 - Long-chain PUFA play an important role in early human neurodevelopment. Significant inverse correlations were reported between values of trans isomeric and long-chain PUFA in plasma lipids of preterm infants and children aged 1-15 yr as well as in venous cord blood lipids of full-term infants. Here we report FA compositional data of cord blood vessel wall lipids in 308 healthy, full-term infants (gestational age: 39.7 ± 1.2 wk, birth weight: 3528 ± 429 g, mean ± SD). The median (interquartile range) of the sum of 18-carbon trans FA was 0.22 (0.13) % w/w in umbilical artery and 0.16 (0.10) % w/w in umbilical vein lipids. Nonparametric correlation analysis showed significant inverse correlations between the sum of 18-carbon trans FA and both arachidonic acid and DHA in artery (r = -0.38, P <0.01, and r = -0.20, P <0.01) and vein (r = -0.36, P <0.01, and -0.17, P <0.01) wall lipids. In addition, the sum of 18-carbon trans FA was significantly positively correlated to Mead acid, a general indicator of EFA deficiency, in both artery (r= +0.35, P <0.01) and vein (r = +0.31, P <0.01) wall lipids. The present results obtained in a large group of full-term infants suggest that maternal trans FA intake is inversely associated with long-chain PUFA status of the infant at birth.

AB - Long-chain PUFA play an important role in early human neurodevelopment. Significant inverse correlations were reported between values of trans isomeric and long-chain PUFA in plasma lipids of preterm infants and children aged 1-15 yr as well as in venous cord blood lipids of full-term infants. Here we report FA compositional data of cord blood vessel wall lipids in 308 healthy, full-term infants (gestational age: 39.7 ± 1.2 wk, birth weight: 3528 ± 429 g, mean ± SD). The median (interquartile range) of the sum of 18-carbon trans FA was 0.22 (0.13) % w/w in umbilical artery and 0.16 (0.10) % w/w in umbilical vein lipids. Nonparametric correlation analysis showed significant inverse correlations between the sum of 18-carbon trans FA and both arachidonic acid and DHA in artery (r = -0.38, P <0.01, and r = -0.20, P <0.01) and vein (r = -0.36, P <0.01, and -0.17, P <0.01) wall lipids. In addition, the sum of 18-carbon trans FA was significantly positively correlated to Mead acid, a general indicator of EFA deficiency, in both artery (r= +0.35, P <0.01) and vein (r = +0.31, P <0.01) wall lipids. The present results obtained in a large group of full-term infants suggest that maternal trans FA intake is inversely associated with long-chain PUFA status of the infant at birth.

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