Traitors of the immune system-Enhancing antibodies in HIV infection

Their possible implication in HIV vaccine development

Zoltán Beck, Z. Prohászka, G. Füst

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Considering recent HIV vaccine failures, the authors believe that it would be most important to find new targets for vaccine-induced immunity, and to analyze the data from previous trials, using an innovative approach. In their review article, the authors briefly summarize the significance of the antibody-dependent enhancement of infection in different viral diseases and discuss role of these types of antibodies as the obstacles for vaccine development. Findings which indicate that complement-mediated antibody-dependent enhancement (C-ADE) is present also in HIV-infected patients, are summarized. Previous results of the authors, suggesting that C-ADE plays a very important role in the progression of HIV infection are described. Data reflecting that enhancing antibodies may develop even in vaccinated animals and human volunteers, and may be responsible for the paradoxical results obtained in some subgroups of vaccinees are discussed. Finally, based on their hypothesis, the authors offer some suggestions for the future development of vaccines.

Original languageEnglish
Pages (from-to)3078-3085
Number of pages8
JournalVaccine
Volume26
Issue number24
DOIs
Publication statusPublished - Jun 6 2008

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Antibody-Dependent Enhancement
AIDS Vaccines
Blocking Antibodies
vaccine development
HIV infections
HIV Infections
immune system
Immune System
Vaccines
antibodies
Virus Diseases
complement
Volunteers
Immunity
vaccines
HIV
Antibodies
volunteers
Infection
immunity

Keywords

  • Antibodies
  • C-ADE
  • Complement
  • Enhancement
  • Enhancing
  • Fc-receptor
  • HIV
  • Vaccine

ASJC Scopus subject areas

  • Immunology
  • Microbiology
  • Virology
  • Infectious Diseases
  • Public Health, Environmental and Occupational Health
  • veterinary(all)

Cite this

Traitors of the immune system-Enhancing antibodies in HIV infection : Their possible implication in HIV vaccine development. / Beck, Zoltán; Prohászka, Z.; Füst, G.

In: Vaccine, Vol. 26, No. 24, 06.06.2008, p. 3078-3085.

Research output: Contribution to journalArticle

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