Tracking the physical aging of poly(ethylene oxide): A technical note

Dorottya Kiss, Karoly Süvegh, Tamas Marek, Laszlo Dévényi, Csaba Novák, Romána Zelkó

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Physical aging of 2 types of PEO could be tracked by the combination of PALS, DSC, and SEM methods. After storing the samples a 40°C ± 2°C and 75% ± 5% RH, a decrease in the o-Ps lifetime values and an increase in the melting enthalpies as a function of storage time indicated a reorientation of the polymer chains. The limitations of monitoring enthalpy relaxation confirm the importance of methods that track volume relaxation, such as PALS. Structural changes could be observed even after a short storage time (4 weeks), which highlights the effect of further investigations of the influence of physical aging on the properties of PEO-containing dosage forms.

Original languageEnglish
Article number95
JournalAAPS PharmSciTech
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 15 2006

Keywords

  • Amorphous
  • Differential scanning calorimetry
  • Physical aging
  • Poly(ethylene oxide)
  • Positron annihilation lifetime spectroscopy

ASJC Scopus subject areas

  • Pharmaceutical Science

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