Tracking the migration of cardially delivered therapeutic stem cells in vivo: State of the art

N. Nyolczas, S. Charwat, A. Posa, R. Hemetsberger, N. Pavo, H. Hemetsberger, I. J. Pavo, D. Glogar, G. Maurer, Mariann Gyöngyösi

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Cell-based therapy is a promising, novel therapeutic strategy for cardiovascular disease. The rapid transition of this approach from the benchside to clinical trials has left a gap in the understanding of the mechanisms of cell therapy. Monitoring of cell homing and the fate of cardially delivered stem cells is fundamental for clarification of the myocardial regenerative process. Noninvasive imaging techniques allow an in vivo evaluation of the survival, migration and differentiation of implanted stem cells over time, and by this means, can help to answer unresolved questions. The most promising in vivo tracking methods involve the direct, nonspecific labeling of cells including MRI, radionuclide imaging and the use of reporter-gene imaging. This review summarizes the most important results of animal and human studies in which the fate and biodistribution of cardially delivered stem cells are assessed through different in vivo tracking methods.

Original languageEnglish
Pages (from-to)407-422
Number of pages16
JournalRegenerative Medicine
Volume4
Issue number3
DOIs
Publication statusPublished - Oct 27 2009

Keywords

  • In vivo tracking
  • MRI
  • PET
  • Reporter gene
  • Stem cell
  • Transfection

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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    Nyolczas, N., Charwat, S., Posa, A., Hemetsberger, R., Pavo, N., Hemetsberger, H., Pavo, I. J., Glogar, D., Maurer, G., & Gyöngyösi, M. (2009). Tracking the migration of cardially delivered therapeutic stem cells in vivo: State of the art. Regenerative Medicine, 4(3), 407-422. https://doi.org/10.2217/rme.09.14