Tracking of the micro-structural changes of levonorgestrel-releasing intrauterine system by positron annihilation lifetime spectroscopy

Kálmán Patai, Virág Szente, Károly Süvegh, Romána Zelkó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The morphology and the micro-structural changes of levonorgestrel-releasing intrauterine systems (IUSs) were studied in relation to the duration of their application. The morphology of the removed IUSs was examined without pre-treatment by scanning electron microscopy. The micro-structural changes of the different layers of IUSs were tracked by positron annihilation lifetime spectroscopy. Besides the previously found incrustation formation, the free volume of the hormone containing reservoir was remarkably increased after 3 years of application, thus increasing the real volume of the core of the systems. Although the free volume of the membrane encasing the core was not significantly changed in the course of the application, as a result of the core expansion, microcracks could be formed on the membrane surface. Along these cracks, deposits of different compositions can be formed, causing inflammatory complications and influencing the drug release of IUSs. Stability tests in combination with micro-structural screening of such IUSs could be required during their development phase to avoid the undesired side effects.

Original languageEnglish
Pages (from-to)902-905
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume53
Issue number4
DOIs
Publication statusPublished - Dec 1 2010

Keywords

  • Incrustation
  • Levonorgestrel-releasing intrauterine system
  • Micro-structural changes
  • Positron lifetime spectroscopy
  • Scanning electron microscopy

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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