Tracking of the kinetic stability of 2 types of total nutrient admixtures containing different lipid emulsions

Judit Balogh, Dorottya Kiss, Judit Dredán, István Puskás, F. Csempesz, R. Zelkó

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The physical stability of 2 types of total nutrient admixtures was studied as a function of storage time and temperature. One of them contained only structured triglycerides and the other exclusively long-chain triglycerides as lipid components. To evaluate the possible changes in the kinetic stability of the emulsions and in the surface characteristics of the droplets during storage, particle size analysis, zeta potential, and dynamic surface tension measurements were performed. To follow any chemical decomposition processes that occurred during storage, the pH of the emulsions was also monitored. The mean droplet size of emulsions prepared with lipids containing exclusively long-chain triglycerides showed a remarkable increase after 4 days of storage, in contrast with that of the mixtures containing structured lipids. A combination of size distribution, zeta potential, and dynamic surface tension measurements proved to be useful for an adequate tracking of the kinetic stability of total nutrient admixtures. Structured triglycerides not only provide advantageous metabolic effects but improve the physical stability of total parenteral nutrition admixtures.

Original languageEnglish
Article number98
JournalAAPS PharmSciTech
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 22 2006

Fingerprint

Emulsions
long chain triacylglycerols
emulsions
Triglycerides
surface tension
Lipids
kinetics
Food
Surface Tension
nutrients
lipids
triacylglycerols
structured lipids
chemical degradation
Chemical Phenomena
droplet size
total parenteral nutrition
storage temperature
droplets
Total Parenteral Nutrition

Keywords

  • Dynamic surface tension
  • Kinetic stability
  • Long-chain triglycerides
  • Nutrient admixtures
  • Structured triglycerides
  • Zeta potential

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science

Cite this

Tracking of the kinetic stability of 2 types of total nutrient admixtures containing different lipid emulsions. / Balogh, Judit; Kiss, Dorottya; Dredán, Judit; Puskás, István; Csempesz, F.; Zelkó, R.

In: AAPS PharmSciTech, Vol. 7, No. 4, 98, 22.12.2006.

Research output: Contribution to journalArticle

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