Tracking of the effects of the plasticizer on the water uptake and free volume changes of methylcellulose

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Abstract

The structural changes in methylcellulose containing poly(ethylene glycol) (PEG 400) as plasticizer caused by water absorption during storage were evaluated. In order to elucidate the structural changes in the polymer, water-uptake measurements and positron annihilation lifetime spectroscopy (PALS) were utilized. The PEG concentrations relative to the total polymer content were varied within the range 0-75% w/w. The Doppler-spectra were characterized by means of the conventional parameters S and W. A transition from a single phase to two phases was found in the methylcellulose films above PEG; a content of 33% w/w. The first step of ageing is merely a conformational change, after which the electron structure remains more or less the same, while both S and W indicate significant changes during the second slow step of ageing. Accurate determination of the plasticizer concentration relating to the single-phase to two-phase transition of Metolose-PEG films has a great impact from the aspect of the application of a stable composition for coating of solid dosage forms.

Original languageEnglish
Pages (from-to)921-924
Number of pages4
JournalPolymers for Advanced Technologies
Volume18
Issue number11
DOIs
Publication statusPublished - Nov 2007

Fingerprint

Plasticizers
Methylcellulose
Free volume
Polyethylene glycols
Water
Polymers
Aging of materials
Positron annihilation
Dosage Forms
Water absorption
Phase transitions
Spectroscopy
Coatings
Electrons
Chemical analysis

Keywords

  • Methylcellulose
  • Poly(ethylene glycol) (PEG 400)
  • Positron annihilation lifetime spectroscopy (PALS)
  • Single-phase to two-phase transition
  • Water-uptake

ASJC Scopus subject areas

  • Polymers and Plastics

Cite this

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title = "Tracking of the effects of the plasticizer on the water uptake and free volume changes of methylcellulose",
abstract = "The structural changes in methylcellulose containing poly(ethylene glycol) (PEG 400) as plasticizer caused by water absorption during storage were evaluated. In order to elucidate the structural changes in the polymer, water-uptake measurements and positron annihilation lifetime spectroscopy (PALS) were utilized. The PEG concentrations relative to the total polymer content were varied within the range 0-75{\%} w/w. The Doppler-spectra were characterized by means of the conventional parameters S and W. A transition from a single phase to two phases was found in the methylcellulose films above PEG; a content of 33{\%} w/w. The first step of ageing is merely a conformational change, after which the electron structure remains more or less the same, while both S and W indicate significant changes during the second slow step of ageing. Accurate determination of the plasticizer concentration relating to the single-phase to two-phase transition of Metolose-PEG films has a great impact from the aspect of the application of a stable composition for coating of solid dosage forms.",
keywords = "Methylcellulose, Poly(ethylene glycol) (PEG 400), Positron annihilation lifetime spectroscopy (PALS), Single-phase to two-phase transition, Water-uptake",
author = "K. Pintye-H{\'o}di and K. S{\"u}vegh and T. Marek and R. Zelk{\'o}",
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AU - Pintye-Hódi, K.

AU - Süvegh, K.

AU - Marek, T.

AU - Zelkó, R.

PY - 2007/11

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N2 - The structural changes in methylcellulose containing poly(ethylene glycol) (PEG 400) as plasticizer caused by water absorption during storage were evaluated. In order to elucidate the structural changes in the polymer, water-uptake measurements and positron annihilation lifetime spectroscopy (PALS) were utilized. The PEG concentrations relative to the total polymer content were varied within the range 0-75% w/w. The Doppler-spectra were characterized by means of the conventional parameters S and W. A transition from a single phase to two phases was found in the methylcellulose films above PEG; a content of 33% w/w. The first step of ageing is merely a conformational change, after which the electron structure remains more or less the same, while both S and W indicate significant changes during the second slow step of ageing. Accurate determination of the plasticizer concentration relating to the single-phase to two-phase transition of Metolose-PEG films has a great impact from the aspect of the application of a stable composition for coating of solid dosage forms.

AB - The structural changes in methylcellulose containing poly(ethylene glycol) (PEG 400) as plasticizer caused by water absorption during storage were evaluated. In order to elucidate the structural changes in the polymer, water-uptake measurements and positron annihilation lifetime spectroscopy (PALS) were utilized. The PEG concentrations relative to the total polymer content were varied within the range 0-75% w/w. The Doppler-spectra were characterized by means of the conventional parameters S and W. A transition from a single phase to two phases was found in the methylcellulose films above PEG; a content of 33% w/w. The first step of ageing is merely a conformational change, after which the electron structure remains more or less the same, while both S and W indicate significant changes during the second slow step of ageing. Accurate determination of the plasticizer concentration relating to the single-phase to two-phase transition of Metolose-PEG films has a great impact from the aspect of the application of a stable composition for coating of solid dosage forms.

KW - Methylcellulose

KW - Poly(ethylene glycol) (PEG 400)

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KW - Single-phase to two-phase transition

KW - Water-uptake

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