Traceless chirality transfer from a norbornene β-amino acid to pyrimido[2,1-a]isoindole enantiomers

Ferenc Miklós, Kristóf Bozó, Zsolt Galla, Matti Haukka, F. Fülöp

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4 Citations (Scopus)

Abstract

The synthesis of two enantiomeric pairs of pyrimidoisoindoles 9a, 9b and 10a, 10b is reported. During a domino ring-closure reaction, followed by cycloreversion, the chirality of diendo-(−)-(1R,2S,3R,4S)-3-aminobicyclo[2.2.1]hept-5-ene-2-carboxamide [(−)-1] was successfully transfered to heterocycles (+)-9a, (+)-10a, (−)-9b, (−)-10b and (−)-10c.

Original languageEnglish
Pages (from-to)1401-1406
Number of pages6
JournalTetrahedron Asymmetry
Volume28
Issue number10
DOIs
Publication statusPublished - Oct 15 2017

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ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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