Towards understanding protein disorder In-Cell

Cesyen Cedeño, Hadas Raveh-Amit, A. Dinnyés, Peter Tompa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Investigating the activity and structure of cellular biochemical machinery at atomic resolution has been a point of paramount significance for understanding health and disease over the decades. The underlying molecular mechanisms are primarily studied in vitro. Nuclear magnetic resonance (NMR) is a technique that allows to look into cells and study proteins and other constituents, thanks to careful experimental design and technological advances (spectrometer sensitivity and pulse sequence design). Here we outline current applications of the technique and propose a realistic future for the field.

Original languageEnglish
Title of host publicationIntrinsically Disordered Proteins Studied by NMR Spectroscopy
PublisherSpringer International Publishing
Pages319-334
Number of pages16
ISBN (Print)9783319201641, 9783319201634
DOIs
Publication statusPublished - Sep 19 2015

Fingerprint

Cellular Structures
Design of experiments
Machinery
Spectrometers
Research Design
Magnetic Resonance Spectroscopy
Nuclear magnetic resonance
Health
Proteins
In Vitro Techniques

Keywords

  • Cell extracts
  • Cell types
  • In-cell NMR
  • Isotopic labeling

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Cedeño, C., Raveh-Amit, H., Dinnyés, A., & Tompa, P. (2015). Towards understanding protein disorder In-Cell. In Intrinsically Disordered Proteins Studied by NMR Spectroscopy (pp. 319-334). Springer International Publishing. https://doi.org/10.1007/978-3-319-20164-1_10

Towards understanding protein disorder In-Cell. / Cedeño, Cesyen; Raveh-Amit, Hadas; Dinnyés, A.; Tompa, Peter.

Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing, 2015. p. 319-334.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cedeño, C, Raveh-Amit, H, Dinnyés, A & Tompa, P 2015, Towards understanding protein disorder In-Cell. in Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing, pp. 319-334. https://doi.org/10.1007/978-3-319-20164-1_10
Cedeño C, Raveh-Amit H, Dinnyés A, Tompa P. Towards understanding protein disorder In-Cell. In Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing. 2015. p. 319-334 https://doi.org/10.1007/978-3-319-20164-1_10
Cedeño, Cesyen ; Raveh-Amit, Hadas ; Dinnyés, A. ; Tompa, Peter. / Towards understanding protein disorder In-Cell. Intrinsically Disordered Proteins Studied by NMR Spectroscopy. Springer International Publishing, 2015. pp. 319-334
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