Towards understanding protein disorder in-cell

Cesyen Cedeño, Hadas Raveh-Amit, András Dinnyés, Peter Tompa

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Investigating the activity and structure of cellular biochemical machinery at atomic resolution has been a point of paramount significance for understanding health and disease over the decades. The underlying molecular mechanisms are primarily studied in vitro. Nuclear magnetic resonance (NMR) is a technique that allows to look into cells and study proteins and other constituents, thanks to careful experimental design and technological advances (spectrometer sensitivity and pulse sequence design). Here we outline current applications of the technique and propose a realistic future for the field.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages319-334
Number of pages16
DOIs
Publication statusPublished - Sep 22 2015

Publication series

NameAdvances in Experimental Medicine and Biology
Volume870
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cell extracts
  • Cell types
  • In-cell NMR
  • Isotopic labeling

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Cedeño, C., Raveh-Amit, H., Dinnyés, A., & Tompa, P. (2015). Towards understanding protein disorder in-cell. In Advances in Experimental Medicine and Biology (pp. 319-334). (Advances in Experimental Medicine and Biology; Vol. 870). Springer New York LLC. https://doi.org/10.1007/978-3-319-20164-1_10