Towards synthetic vaccines built on carbohydrate cores

Ross P. Mcgeary, Istvan Jablonkai, Istvan Toth

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Lipophilic polyfunctional carbohydrate core/templates have been designed and developed for drug/vaccine delivery. Three carbohydrate-based templates containing four protected N-terminal arms were synthesised from glucose and galactose. Methyl α-D-glucopyranoside was converted to two derivatives bearing a carboxylic acid handle for attachment to solid supports, spacer arms of differing hydrophilicity, and phthaloyl-protected amino groups suitable for peptide chain extension. β-D-Galactopyranosyl azide was converted to a template bearing a carboxylic acid handle and four BOC-protected amines. All the templates were found to be suitable for attachment to solid supports and subsequent cleavage from resins, using either BOC- or FMOC-methodologies.

Original languageEnglish
Pages (from-to)273-276
Number of pages4
JournalLetters in Peptide Science
Volume8
Issue number3-5
DOIs
Publication statusPublished - May 2001

Keywords

  • Adjuvants/carriers
  • Carbohydrates
  • Solid-phase peptide synthesis
  • Synthetic vaccines

ASJC Scopus subject areas

  • Biochemistry

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