Towards a more physiological approach in GABA binding

Julianna Kardos, Katalin Maderspach, Miklós Simonyi

Research output: Contribution to journalArticle

9 Citations (Scopus)


Gamma-aminobutyric acid (GABA) mediates the postsynaptic inhibition via reversible binding to specific recognition (receptor) sites. Despite extensive research, the results from binding and functional response measurements remains controversial. It is suggested that controversies may partly result from the use of non-physiological buffer during the preparation and binding assay of the GABA receptor. To account for the positive cooperativity found in physiological medium, a hypothetical model of the GABA receptor is proposed as a tetramer of binding sites operating in a cooperative fashion.

Original languageEnglish
Pages (from-to)737-743
Number of pages7
JournalNeurochemistry international
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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