Toward synthesis of the isosteric sulfonate analogues of the at-iii binding domain of heparin

Mihály Herczeg, László Lázár, Anikó Borbás, András Lipták, Sándor Antus

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

D-Glucuronate and L-iduronate containing disaccharides related to the antithrombin-binding pentasaccharide of heparin, in which one of the sulfate esters is systematically replaced by a sodium sulfonatomethyl moiety, were synthesized. The sulfonic acid group was introduced by stereoselective radical addition onto the exomethylene moiety of the appropriate glycoside derivatives, and the resulting sulfonatomethyl glucosides were used as acceptors.

Original languageEnglish
Pages (from-to)2619-2622
Number of pages4
JournalOrganic Letters
Volume11
Issue number12
DOIs
Publication statusPublished - Jun 18 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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