Toward synthesis of the isosteric sulfonate analogues of the at-iii binding domain of heparin

Mihály Herczeg; László Lázár; Anikó Borbás; András Lipták; Sándor Antus

doi:10.1021/ol900952d

Toward synthesis of the isosteric sulfonate analogues of the at-iii binding domain of heparin

Mihály Herczeg, László Lázár, Anikó Borbás, András Lipták, Sándor Antus

University of Debrecen

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

D-Glucuronate and L-iduronate containing disaccharides related to the antithrombin-binding pentasaccharide of heparin, in which one of the sulfate esters is systematically replaced by a sodium sulfonatomethyl moiety, were synthesized. The sulfonic acid group was introduced by stereoselective radical addition onto the exomethylene moiety of the appropriate glycoside derivatives, and the resulting sulfonatomethyl glucosides were used as acceptors.

Original language	English
Pages (from-to)	2619-2622
Number of pages	4
Journal	Organic Letters
Volume	11
Issue number	12
DOIs	https://doi.org/10.1021/ol900952d
Publication status	Published - Jun 18 2009

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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Herczeg, M., Lázár, L., Borbás, A., Lipták, A., & Antus, S. (2009). Toward synthesis of the isosteric sulfonate analogues of the at-iii binding domain of heparin. Organic Letters, 11(12), 2619-2622. https://doi.org/10.1021/ol900952d

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AU - Antus, Sándor

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