Total body irradiation before bone marrow transplantation technique and acute toxicity

Judit Székely, László Fábry, Gyula Forgács, Gábor Kontra, Julia Petrányi, O. Ésik, György Németh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: To evaluate the total body irradiation methods in the National Institute of Oncology between January 1984 and February 1998. Patients and Methods: One hundred and twenty-four patients underwent total body irradiation prior to bone marrow transplantation in the last 15 years. A special cobalt unit has been used, the dose rate was 6 to 8 cGy/min in the midline of the abdomen. The source-midline distance (SMD) was 340 cm and the field size was 80 X 200 cm. The dose calculation was done on the basis of a tissue-phantom ratio curve measured in total body irradiation conditions and effective tissue thickness (ETT). Between 1984 and 1992 the beam direction was horizontal, the patients laid in lateral position. In 11 cases the total dose to the abdominal midline was 10 Gy, in 1 fraction. From 1986 the fractionation changed to 4 x 3 Gy in 4 days. With individual lung shielding the average lung dose was 8.5 Gy. In 44/124 cases the order of conditioning treatment was chemo-radiotherapy. Since 1992 vertical beams were used, and the patients (80/124) laid in prone/supine position. The fractionation remained the same but radio-chemotherapy regime has been used. Results: The irradiation in prone position proved to be safer than lateral because of smaller patient motion and it resulted in a more accurate positioning of lung shielding, too. In all cases, the acute side effects (headache, nausea, vomiting) were moderate. Using radio-chemotherapy the acute side effects during the total body irradiation were uncommon and well tolerable. Conclusion: Our technique with the large source-midline distance, vertical beam direction and the supine/prone position is stable, convenient and safe to produce homogeneous dose distribution and ensures accurate and reproducible lung shielding.

Original languageEnglish
Pages (from-to)606-610
Number of pages5
JournalStrahlentherapie und Onkologie
Volume175
Issue number12
DOIs
Publication statusPublished - Dec 1999

Fingerprint

Whole-Body Irradiation
Bone Marrow Transplantation
Prone Position
Lung
Supine Position
Radio
Drug Therapy
Cobalt
Abdomen
Nausea
Vomiting
Headache
Radiotherapy
Direction compound

Keywords

  • Cobalt source
  • Effective tissue thickness
  • Fractionation
  • Total body irradiation

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cancer Research
  • Radiological and Ultrasound Technology

Cite this

Székely, J., Fábry, L., Forgács, G., Kontra, G., Petrányi, J., Ésik, O., & Németh, G. (1999). Total body irradiation before bone marrow transplantation technique and acute toxicity. Strahlentherapie und Onkologie, 175(12), 606-610. https://doi.org/10.1007/s000660050048

Total body irradiation before bone marrow transplantation technique and acute toxicity. / Székely, Judit; Fábry, László; Forgács, Gyula; Kontra, Gábor; Petrányi, Julia; Ésik, O.; Németh, György.

In: Strahlentherapie und Onkologie, Vol. 175, No. 12, 12.1999, p. 606-610.

Research output: Contribution to journalArticle

Székely, J, Fábry, L, Forgács, G, Kontra, G, Petrányi, J, Ésik, O & Németh, G 1999, 'Total body irradiation before bone marrow transplantation technique and acute toxicity', Strahlentherapie und Onkologie, vol. 175, no. 12, pp. 606-610. https://doi.org/10.1007/s000660050048
Székely, Judit ; Fábry, László ; Forgács, Gyula ; Kontra, Gábor ; Petrányi, Julia ; Ésik, O. ; Németh, György. / Total body irradiation before bone marrow transplantation technique and acute toxicity. In: Strahlentherapie und Onkologie. 1999 ; Vol. 175, No. 12. pp. 606-610.
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