Topography of the somatostatin-immunoreactive fibers to the stalk-median eminence of the rat

G. Makara, M. Palkóvits, Ferenc A. Antoni, J. Kiss

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The course of the hypothalamo-infundibular somatostatin containing pathway was visualized by immunocytochemistry (the unlabeled antibody peroxidase-antiperoxidase complex method) combined with various knife cuts in the hypothalamus. Somatostatin immunoreactive fibers left the perikarya in the anterior hypothalamic-preoptic periventricular cell mass in a lateral direction. After a loop-like path through the lateral hypothalamus, fibers enter the medial basal hypothalamus mainly in the lateral retrochiasmatic area near the ventral surface and project to the ipsilateral half of the median eminence and the pituitary stalk. Somatostatin immunoreactivity almost completely disappeared from the stalk-median eminence 3–7 days following a complete anterolateral transection while transections dorsal or posterior to the lateral retrochiasmatic area failed to influence it. 7 weeks after anterolateral deafferentation an increased density of somatostatin containing terminals and immunopositive perikarya were seen in the arcuate and ventromedial nuclei but these neurones failed to reinnervate the stalk-median eminence.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalNeuroendocrinology
Volume37
Issue number1
DOIs
Publication statusPublished - 1983

Fingerprint

Median Eminence
Somatostatin
Lateral Hypothalamic Area
Middle Hypothalamus
Arcuate Nucleus of Hypothalamus
Pituitary Gland
Peroxidase
Hypothalamus
Immunohistochemistry
Neurons
Antibodies

Keywords

  • Growth hormone release
  • Hypothalamic deafferentation
  • Hypothalamus
  • Immunocytochemistry
  • Knife cut
  • Somatostatin
  • SRIF

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neuroscience(all)

Cite this

Topography of the somatostatin-immunoreactive fibers to the stalk-median eminence of the rat. / Makara, G.; Palkóvits, M.; Antoni, Ferenc A.; Kiss, J.

In: Neuroendocrinology, Vol. 37, No. 1, 1983, p. 1-8.

Research output: Contribution to journalArticle

@article{21e224cdb61f4a60bfe3cc1a33d28148,
title = "Topography of the somatostatin-immunoreactive fibers to the stalk-median eminence of the rat",
abstract = "The course of the hypothalamo-infundibular somatostatin containing pathway was visualized by immunocytochemistry (the unlabeled antibody peroxidase-antiperoxidase complex method) combined with various knife cuts in the hypothalamus. Somatostatin immunoreactive fibers left the perikarya in the anterior hypothalamic-preoptic periventricular cell mass in a lateral direction. After a loop-like path through the lateral hypothalamus, fibers enter the medial basal hypothalamus mainly in the lateral retrochiasmatic area near the ventral surface and project to the ipsilateral half of the median eminence and the pituitary stalk. Somatostatin immunoreactivity almost completely disappeared from the stalk-median eminence 3–7 days following a complete anterolateral transection while transections dorsal or posterior to the lateral retrochiasmatic area failed to influence it. 7 weeks after anterolateral deafferentation an increased density of somatostatin containing terminals and immunopositive perikarya were seen in the arcuate and ventromedial nuclei but these neurones failed to reinnervate the stalk-median eminence.",
keywords = "Growth hormone release, Hypothalamic deafferentation, Hypothalamus, Immunocytochemistry, Knife cut, Somatostatin, SRIF",
author = "G. Makara and M. Palk{\'o}vits and Antoni, {Ferenc A.} and J. Kiss",
year = "1983",
doi = "10.1159/000123508",
language = "English",
volume = "37",
pages = "1--8",
journal = "Neuroendocrinology",
issn = "0028-3835",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Topography of the somatostatin-immunoreactive fibers to the stalk-median eminence of the rat

AU - Makara, G.

AU - Palkóvits, M.

AU - Antoni, Ferenc A.

AU - Kiss, J.

PY - 1983

Y1 - 1983

N2 - The course of the hypothalamo-infundibular somatostatin containing pathway was visualized by immunocytochemistry (the unlabeled antibody peroxidase-antiperoxidase complex method) combined with various knife cuts in the hypothalamus. Somatostatin immunoreactive fibers left the perikarya in the anterior hypothalamic-preoptic periventricular cell mass in a lateral direction. After a loop-like path through the lateral hypothalamus, fibers enter the medial basal hypothalamus mainly in the lateral retrochiasmatic area near the ventral surface and project to the ipsilateral half of the median eminence and the pituitary stalk. Somatostatin immunoreactivity almost completely disappeared from the stalk-median eminence 3–7 days following a complete anterolateral transection while transections dorsal or posterior to the lateral retrochiasmatic area failed to influence it. 7 weeks after anterolateral deafferentation an increased density of somatostatin containing terminals and immunopositive perikarya were seen in the arcuate and ventromedial nuclei but these neurones failed to reinnervate the stalk-median eminence.

AB - The course of the hypothalamo-infundibular somatostatin containing pathway was visualized by immunocytochemistry (the unlabeled antibody peroxidase-antiperoxidase complex method) combined with various knife cuts in the hypothalamus. Somatostatin immunoreactive fibers left the perikarya in the anterior hypothalamic-preoptic periventricular cell mass in a lateral direction. After a loop-like path through the lateral hypothalamus, fibers enter the medial basal hypothalamus mainly in the lateral retrochiasmatic area near the ventral surface and project to the ipsilateral half of the median eminence and the pituitary stalk. Somatostatin immunoreactivity almost completely disappeared from the stalk-median eminence 3–7 days following a complete anterolateral transection while transections dorsal or posterior to the lateral retrochiasmatic area failed to influence it. 7 weeks after anterolateral deafferentation an increased density of somatostatin containing terminals and immunopositive perikarya were seen in the arcuate and ventromedial nuclei but these neurones failed to reinnervate the stalk-median eminence.

KW - Growth hormone release

KW - Hypothalamic deafferentation

KW - Hypothalamus

KW - Immunocytochemistry

KW - Knife cut

KW - Somatostatin

KW - SRIF

UR - http://www.scopus.com/inward/record.url?scp=0020531006&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020531006&partnerID=8YFLogxK

U2 - 10.1159/000123508

DO - 10.1159/000123508

M3 - Article

C2 - 6136929

AN - SCOPUS:0020531006

VL - 37

SP - 1

EP - 8

JO - Neuroendocrinology

JF - Neuroendocrinology

SN - 0028-3835

IS - 1

ER -