Topography of median eminence somatostatinergic innervation

J. Epelbaum, L. Tapia Arancibia, J. P. Herman, C. Kordon, M. Palkóvits

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Somatostatin (SRIF) in the central nervous system is mostly concentrated in the median eminence (ME). Immunocytochemical methods have revealed high densities of SRIF-positive perikarya between the preoptic area and the periventricular nucleus of the hypothalamus (NPE). The aim of the present study was to define more precisely the specific pathways of SRIF neurons from NPE to the ME. SRIF levels were measured by radioimmunoassay, following various hypothalamic transections. Frontal periventricular sections decreased SRIF-ME content by 70% 9P <0.01), when located at the anterior end of the ME but no diminution was observed when the cuts were located anteriorly or posteriorly. Parasagittal transections decreased SRIF-ME levels by 50% (P <0.05) when located at the outer border of the ventromedial and premammillary nucleus, but the decrease was not significant when cuts were located anteriorly. Taken together, our data indicate that most SRIF-containing neurons, originating in the NPE, do not reach the ME directly along the border of the 3rd ventricle; instead they form a loop across the medial forebrain bundle before re-entering the mediobasal hypothalamus at the ME level.

Original languageEnglish
Pages (from-to)412-416
Number of pages5
JournalBrain Research
Volume230
Issue number1-2
DOIs
Publication statusPublished - Dec 28 1981

Fingerprint

Median Eminence
Hypothalamus
Posterior Hypothalamus
Medial Forebrain Bundle
Neurons
Third Ventricle
Preoptic Area
Somatostatin
Radioimmunoassay
Central Nervous System

Keywords

  • median eminence
  • neuronal pathways
  • radioimmunoassay
  • somatostatin

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Topography of median eminence somatostatinergic innervation. / Epelbaum, J.; Arancibia, L. Tapia; Herman, J. P.; Kordon, C.; Palkóvits, M.

In: Brain Research, Vol. 230, No. 1-2, 28.12.1981, p. 412-416.

Research output: Contribution to journalArticle

Epelbaum, J, Arancibia, LT, Herman, JP, Kordon, C & Palkóvits, M 1981, 'Topography of median eminence somatostatinergic innervation', Brain Research, vol. 230, no. 1-2, pp. 412-416. https://doi.org/10.1016/0006-8993(81)90425-X
Epelbaum, J. ; Arancibia, L. Tapia ; Herman, J. P. ; Kordon, C. ; Palkóvits, M. / Topography of median eminence somatostatinergic innervation. In: Brain Research. 1981 ; Vol. 230, No. 1-2. pp. 412-416.
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