Toll-Like receptors in the pathogenesis of alcoholic liver disease

G. Szabó, Jan Petrasek, Pranoti Mandrekar

Research output: Contribution to journalReview article

52 Citations (Scopus)

Abstract

In the multifactorial pathophysiology of alcoholic liver disease (ALD), inflammatory cascade activation plays a central role. Recent studies demonstrated that Toll-like Receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD. In this paper, we discuss the importance of gut-derived endotoxin and its recognition by TLR4. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of reactive oxygen radicals is evaluated. The contribution of TLR signaling to induction of liver fibrosis and hepatocellular cancer is reviewed in the context of alcohol-induced liver disease.

Original languageEnglish
Article number710381
JournalGastroenterology Research and Practice
DOIs
Publication statusPublished - 2010

Fingerprint

Alcoholic Liver Diseases
Toll-Like Receptors
Liver Neoplasms
Endotoxins
Liver Cirrhosis
Liver Diseases
Reactive Oxygen Species
Alcohols
Cytokines
Liver

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Toll-Like receptors in the pathogenesis of alcoholic liver disease. / Szabó, G.; Petrasek, Jan; Mandrekar, Pranoti.

In: Gastroenterology Research and Practice, 2010.

Research output: Contribution to journalReview article

@article{91c1074b36a34505a4776458f8e2f174,
title = "Toll-Like receptors in the pathogenesis of alcoholic liver disease",
abstract = "In the multifactorial pathophysiology of alcoholic liver disease (ALD), inflammatory cascade activation plays a central role. Recent studies demonstrated that Toll-like Receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD. In this paper, we discuss the importance of gut-derived endotoxin and its recognition by TLR4. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of reactive oxygen radicals is evaluated. The contribution of TLR signaling to induction of liver fibrosis and hepatocellular cancer is reviewed in the context of alcohol-induced liver disease.",
author = "G. Szab{\'o} and Jan Petrasek and Pranoti Mandrekar",
year = "2010",
doi = "10.1155/2010/710381",
language = "English",
journal = "Gastroenterology Research and Practice",
issn = "1687-6121",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Toll-Like receptors in the pathogenesis of alcoholic liver disease

AU - Szabó, G.

AU - Petrasek, Jan

AU - Mandrekar, Pranoti

PY - 2010

Y1 - 2010

N2 - In the multifactorial pathophysiology of alcoholic liver disease (ALD), inflammatory cascade activation plays a central role. Recent studies demonstrated that Toll-like Receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD. In this paper, we discuss the importance of gut-derived endotoxin and its recognition by TLR4. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of reactive oxygen radicals is evaluated. The contribution of TLR signaling to induction of liver fibrosis and hepatocellular cancer is reviewed in the context of alcohol-induced liver disease.

AB - In the multifactorial pathophysiology of alcoholic liver disease (ALD), inflammatory cascade activation plays a central role. Recent studies demonstrated that Toll-like Receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD. In this paper, we discuss the importance of gut-derived endotoxin and its recognition by TLR4. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of reactive oxygen radicals is evaluated. The contribution of TLR signaling to induction of liver fibrosis and hepatocellular cancer is reviewed in the context of alcohol-induced liver disease.

UR - http://www.scopus.com/inward/record.url?scp=77956805892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956805892&partnerID=8YFLogxK

U2 - 10.1155/2010/710381

DO - 10.1155/2010/710381

M3 - Review article

C2 - 20827314

AN - SCOPUS:77956805892

JO - Gastroenterology Research and Practice

JF - Gastroenterology Research and Practice

SN - 1687-6121

M1 - 710381

ER -