Toll-Like Receptors in Liver Disease

Jan Petrasek, Timea Csak, G. Szabó

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Activation of inflammatory signaling pathways is of central importance in the pathogenesis of alcoholic liver disease (ALD) and nonalcoholic steatohepatitis (NASH). Recent studies demonstrated that Toll-like receptors, the sensors of microbial and endogenous danger signals, are expressed and activated in innate immune cells as well as in parenchymal cells in the liver and thereby contribute to ALD and NASH. In this review, we emphasize the importance of gut-derived endotoxin and its recognition by TLR4 in the liver. The significance of TLR-induced intracellular signaling pathways and cytokine production as well as the contribution of individual cell types to the inflammation is evaluated. The contribution of TLR signaling to the induction of liver fibrosis and to the progression of liver pathology mediated by viral pathogens is reviewed in the context of ALD and NASH.

Original languageEnglish
Pages (from-to)155-201
Number of pages47
JournalAdvances in Clinical Chemistry
Volume59
DOIs
Publication statusPublished - 2013

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Alcoholic Liver Diseases
Toll-Like Receptors
Liver
Liver Diseases
Endotoxins
Liver Cirrhosis
Pathology
Cytokines
Inflammation
Pathogens
Non-alcoholic Fatty Liver Disease
Chemical activation
Sensors

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Chemistry(all)

Cite this

Toll-Like Receptors in Liver Disease. / Petrasek, Jan; Csak, Timea; Szabó, G.

In: Advances in Clinical Chemistry, Vol. 59, 2013, p. 155-201.

Research output: Contribution to journalArticle

Petrasek, Jan ; Csak, Timea ; Szabó, G. / Toll-Like Receptors in Liver Disease. In: Advances in Clinical Chemistry. 2013 ; Vol. 59. pp. 155-201.
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