To date the greenest method for the preparation of α-hydroxyphosphonates from substituted benzaldehydes and dialkyl phosphites

G. Keglevich, Zita Rádai, Nóra Zsuzsa Kiss

Research output: Contribution to journalArticle

12 Citations (Scopus)


Recent synthetic methods for α-hydroxyphosphonates comprise a green, solvent-free accomplishment of the Pudovik reaction that was typically followed by extractions and recrystallization, or even by chromatography, or other operations. We now developed a general procedure applying 10% of triethylamine as the catalyst and a minimum quantity of acetone as the solvent, giving the products in a pure form after a reflux of 5-120 min following the addition of some n-pentane and crystallization on cooling.

Original languageEnglish
Pages (from-to)197-201
Number of pages5
JournalGreen Processing and Synthesis
Issue number2
Publication statusPublished - Apr 1 2017



  • green synthesis
  • green work-up
  • Pudovik reaction
  • α-hydroxyphosphonates

ASJC Scopus subject areas

  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment
  • Fuel Technology
  • Industrial and Manufacturing Engineering
  • Health, Toxicology and Mutagenesis

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