TNM stage and grade in predicting the prognosis of operated, non-functioning neuroendocrine carcinoma of the pancreas - A single-institution experience

Franz Sellner, Sabine Thalhammer, Stefan Stättner, J. Karner, Martin Klimpfinger

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective: To evaluate the prognostic significance of TNM and grading categories in curatively resected non-functioning neuroendocrine pancreatic carcinoma (nfnepC). Method: Eighteen nfnepC were retrospectively analyzed for differences in survival. Results: (1) There was a correlation between pT (P = 0.026), respectively pM categories (P = 0.016) and survival. (2) G categories and length of survival were closely correlated (P = 0.0036). (3) Disease stages I-IV had a significant effect on survival (P = 0.051). (4) The WHO classification in well and poorly differentiated carcinomas proved to be the most conclusive predictive factor (P = 0.0009). (5) Subgroups with significantly different prognoses determined by histological grade were present within disease stage II. Conclusions: The retrospective analysis showed a good correlation between survival and pT, pM, tumor stage, G categories, and WHO classification in well and poorly differentiated carcinomas. Including histological differentiation in the staging system or carrying it out separately in well and poorly differentiated carcinomas, could enhance the predictive potential of TNM-based disease stages.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalJournal of Surgical Oncology
Volume104
Issue number1
DOIs
Publication statusPublished - Jul 1 2011

Fingerprint

Neuroendocrine Carcinoma
Pancreas
Carcinoma
Neoplasms
Pancreatic Carcinoma

Keywords

  • Grading
  • Neuroendocrine pancreatic carcinoma
  • Non-functioning
  • Outcome
  • Staging
  • TNM categories

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

TNM stage and grade in predicting the prognosis of operated, non-functioning neuroendocrine carcinoma of the pancreas - A single-institution experience. / Sellner, Franz; Thalhammer, Sabine; Stättner, Stefan; Karner, J.; Klimpfinger, Martin.

In: Journal of Surgical Oncology, Vol. 104, No. 1, 01.07.2011, p. 17-21.

Research output: Contribution to journalArticle

@article{9fdac000faa14f0b9c23696cd2d1dd8f,
title = "TNM stage and grade in predicting the prognosis of operated, non-functioning neuroendocrine carcinoma of the pancreas - A single-institution experience",
abstract = "Objective: To evaluate the prognostic significance of TNM and grading categories in curatively resected non-functioning neuroendocrine pancreatic carcinoma (nfnepC). Method: Eighteen nfnepC were retrospectively analyzed for differences in survival. Results: (1) There was a correlation between pT (P = 0.026), respectively pM categories (P = 0.016) and survival. (2) G categories and length of survival were closely correlated (P = 0.0036). (3) Disease stages I-IV had a significant effect on survival (P = 0.051). (4) The WHO classification in well and poorly differentiated carcinomas proved to be the most conclusive predictive factor (P = 0.0009). (5) Subgroups with significantly different prognoses determined by histological grade were present within disease stage II. Conclusions: The retrospective analysis showed a good correlation between survival and pT, pM, tumor stage, G categories, and WHO classification in well and poorly differentiated carcinomas. Including histological differentiation in the staging system or carrying it out separately in well and poorly differentiated carcinomas, could enhance the predictive potential of TNM-based disease stages.",
keywords = "Grading, Neuroendocrine pancreatic carcinoma, Non-functioning, Outcome, Staging, TNM categories",
author = "Franz Sellner and Sabine Thalhammer and Stefan St{\"a}ttner and J. Karner and Martin Klimpfinger",
year = "2011",
month = "7",
day = "1",
doi = "10.1002/jso.21889",
language = "English",
volume = "104",
pages = "17--21",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - TNM stage and grade in predicting the prognosis of operated, non-functioning neuroendocrine carcinoma of the pancreas - A single-institution experience

AU - Sellner, Franz

AU - Thalhammer, Sabine

AU - Stättner, Stefan

AU - Karner, J.

AU - Klimpfinger, Martin

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Objective: To evaluate the prognostic significance of TNM and grading categories in curatively resected non-functioning neuroendocrine pancreatic carcinoma (nfnepC). Method: Eighteen nfnepC were retrospectively analyzed for differences in survival. Results: (1) There was a correlation between pT (P = 0.026), respectively pM categories (P = 0.016) and survival. (2) G categories and length of survival were closely correlated (P = 0.0036). (3) Disease stages I-IV had a significant effect on survival (P = 0.051). (4) The WHO classification in well and poorly differentiated carcinomas proved to be the most conclusive predictive factor (P = 0.0009). (5) Subgroups with significantly different prognoses determined by histological grade were present within disease stage II. Conclusions: The retrospective analysis showed a good correlation between survival and pT, pM, tumor stage, G categories, and WHO classification in well and poorly differentiated carcinomas. Including histological differentiation in the staging system or carrying it out separately in well and poorly differentiated carcinomas, could enhance the predictive potential of TNM-based disease stages.

AB - Objective: To evaluate the prognostic significance of TNM and grading categories in curatively resected non-functioning neuroendocrine pancreatic carcinoma (nfnepC). Method: Eighteen nfnepC were retrospectively analyzed for differences in survival. Results: (1) There was a correlation between pT (P = 0.026), respectively pM categories (P = 0.016) and survival. (2) G categories and length of survival were closely correlated (P = 0.0036). (3) Disease stages I-IV had a significant effect on survival (P = 0.051). (4) The WHO classification in well and poorly differentiated carcinomas proved to be the most conclusive predictive factor (P = 0.0009). (5) Subgroups with significantly different prognoses determined by histological grade were present within disease stage II. Conclusions: The retrospective analysis showed a good correlation between survival and pT, pM, tumor stage, G categories, and WHO classification in well and poorly differentiated carcinomas. Including histological differentiation in the staging system or carrying it out separately in well and poorly differentiated carcinomas, could enhance the predictive potential of TNM-based disease stages.

KW - Grading

KW - Neuroendocrine pancreatic carcinoma

KW - Non-functioning

KW - Outcome

KW - Staging

KW - TNM categories

UR - http://www.scopus.com/inward/record.url?scp=79958128607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958128607&partnerID=8YFLogxK

U2 - 10.1002/jso.21889

DO - 10.1002/jso.21889

M3 - Article

C2 - 21360536

AN - SCOPUS:79958128607

VL - 104

SP - 17

EP - 21

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 1

ER -