TNF-α receptor expression correlates with histologic activity of otosclerosis

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12 Citations (Scopus)

Abstract

Hypothesis: Otosclerosis is an inflammatory bone remodeling disorder of the human otic capsule, which might be characterized by variable levels and unique expression pattern of TNF-α receptors. Background: Histologic characteristics of otosclerosis have been well described during the latest decades; however, the grading of different histopathologic and clinical stages has not been attributed precisely to the molecular biology of the pathologically increased metabolism of osteoclast-osteoblast axis. Methods: Forty otosclerotic- and 40 nonotosclerotic ankylotic stapes footplates (n = 80; men, 29; women, 51) were histologically analyzed: conventional hematoxylin-eosin staining and tumor necrosis factor-α receptor I and II (TNFRI/II)-specific immunofluorescent assay was performed. Results: Active otosclerosis (Grades I-II; n = 24) was featured by increased expression of TNFRII and moderate expression of TNFRI; inactive cases (Grades III-IV) were characterized by permanent expression of TNFRI; however, TNFRII-specific immunoreaction was absent. Nonotosclerotic stapes specimens showed a negligible TNFR expression. Tumor necrosis factor receptor expression pattern showed a strong correlation with the histologic activity of otosclerosis (χ2 test; p < 0.001). Conclusion: Detection of elevated TNFR expression demonstrates activated osteoclast metabolism and inflammatory pathways in otosclerosis. Different etiopathogenesis of otosclerotic and nonotosclerotic stapes ankylosis should be distinguished. Administration of monoclonal anti-TNF-α antibody may be a reasonable option in the medical treatment of active stages of otosclerosis.

Original languageEnglish
Pages (from-to)1131-1137
Number of pages7
JournalOtology and Neurotology
Volume30
Issue number8
DOIs
Publication statusPublished - Dec 1 2009

Keywords

  • Inflammation
  • Nonotosclerotic stapes fixation
  • Otosclerosis
  • Tumor necrosis factor-α
  • Tumor necrosis factor-α receptors

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

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