TMDET: Web server for detecting transmembrane regions of proteins by using their 3D coordinates

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Summary: The structure of integral membrane proteins is determined in the absence of the lipid bilayer; consequently the membrane localization of the protein is usually not specified in the corresponding PDB file. Recently, we have developed a new method called TMDET which determines the most possible localization of the membrane relative to the protein structure, and gives the annotation of the membrane embedded parts of the sequence. The entire Protein Data Bank has been scanned by the new TMDET algorithm resulting in the database of structurally determined transmembrane proteins (PDB_TM). Here we present the web interface of the TMDET algorithm to allow scientists to determine the membrane localization of structural data prior to deposition or to analyze model structures.

Original languageEnglish
Pages (from-to)1276-1277
Number of pages2
JournalBioinformatics
Volume21
Issue number7
DOIs
Publication statusPublished - Apr 1 2005

Fingerprint

Web Server
Membrane
Servers
Proteins
Membranes
Protein
Membrane Proteins
Databases
Lipid Bilayers
Lipid Bilayer
Membrane Protein
Lipid bilayers
Protein Structure
Model structures
Annotation
Entire
Model

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Computer Science Applications
  • Computational Theory and Mathematics

Cite this

TMDET : Web server for detecting transmembrane regions of proteins by using their 3D coordinates. / Tusnády, G.; Dosztányi, Z.; Simon, I.

In: Bioinformatics, Vol. 21, No. 7, 01.04.2005, p. 1276-1277.

Research output: Contribution to journalArticle

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