TLR4, ethanol, and lipid rafts: A new mechanism of ethanol action with implications for other receptor-mediated effects

G. Szabó, Angela Dolganiuc, Qun Dai, Stephen B. Pruett

Research output: Contribution to journalShort survey

102 Citations (Scopus)

Abstract

Ethanol (EtOH) is the most widely abused substance in the United States, and it contributes to well-documented harmful (at high dosages) and beneficial (at low dosages) changes in inflammatory and immune responses. Lipid rafts have been implicated in the regulation and activation of several important receptor complexes in the immune system, including the TLR4 complex. Many questions remain about the precise mechanisms by which rafts regulate the assembly of these receptor complexes. Results summarized in this review indicate that EtOH acts by altering the LPS-induced redistribution of components of the TLR4 complex within the lipid raft and that this is related to changes in actin cytoskeleton rearrangement, receptor clustering, and subsequent signaling. EtOH provides an example of an immunomodulatory drug that acts at least in pan by modifying lipid rafts, and it could represent a model to probe the relationships between rafts, receptor complexes, and signaling.

Original languageEnglish
Pages (from-to)1243-1249
Number of pages7
JournalJournal of Immunology
Volume178
Issue number3
Publication statusPublished - Feb 1 2007

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Ethanol
Lipids
Actin Cytoskeleton
Cluster Analysis
Immune System
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology

Cite this

TLR4, ethanol, and lipid rafts : A new mechanism of ethanol action with implications for other receptor-mediated effects. / Szabó, G.; Dolganiuc, Angela; Dai, Qun; Pruett, Stephen B.

In: Journal of Immunology, Vol. 178, No. 3, 01.02.2007, p. 1243-1249.

Research output: Contribution to journalShort survey

Szabó, G. ; Dolganiuc, Angela ; Dai, Qun ; Pruett, Stephen B. / TLR4, ethanol, and lipid rafts : A new mechanism of ethanol action with implications for other receptor-mediated effects. In: Journal of Immunology. 2007 ; Vol. 178, No. 3. pp. 1243-1249.
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