TLC investigation of some morphine derivatives

H. Kalasz, L. Kerecsen, T. Csermely, H. Gotz, T. Friedmann, S. Hosztafi

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Morphine and its semisynthetic derivatives can be well separated on silica gel TLC plates by use of various mobile phases. The major mode of separation is elution; some of these compounds are, however, displaced when chloroform - triethanolamine (95 + 5, v/v) is used as mobile phase. Reversed phase TLC has been used to characterize the lipophilicity of morphine derivatives. The stationary phase was prepared by impregnation of the silica gel plate with hexane containing 5% paraffin oil and the compounds were chromatographed with various water methanol mixtures. The Quattro Pro spreadsheet program was used to determine approximate R(M) values corresponding to 0% methanol and the slopes of plots of R(M) against methanol content.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalJournal of Planar Chromatography - Modern TLC
Issue number1
Publication statusPublished - Jan 1 1995



  • displacement TLC
  • lipophilicity determination
  • morphine
  • morphine derivatives
  • reversed phase TLC

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Clinical Biochemistry

Cite this

Kalasz, H., Kerecsen, L., Csermely, T., Gotz, H., Friedmann, T., & Hosztafi, S. (1995). TLC investigation of some morphine derivatives. Journal of Planar Chromatography - Modern TLC, 8(1), 17-22.