T 1-relaxációs ido{combining double acute accent}n alapuló agyi víztartalom-meghatározás és kvantitatív 1H-MRS 3 T térero{combining double acute accent}n

Translated title of the contribution: Tissue water content determination based on T 1 relaxation time of water and quantitative cerebral 1H MRS at 3T using water as an internal reference

Györgyi File, Gábor Bajzik, T. Dóczi, Gergely Orsi, Gábor Perlaki, Zsuzsanna Lelovics, Míhaly Aradi, Attila Schwarcz

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective - Application of a quantitative MR-spectroscopic method for 3T clinical scanners based on tissue water content as an internal reference. Patients and methods - Six (22 ± 2 yrs) volunteers were involved in the study. We performed T 1 relaxation time measurements in a particular slice of the brain at 1T and 3T. Based on the validated water content measurement at 1T, the correlation of relaxation time T 1 and water content was determined at 3T. The resulting water content served as internal reference for the quantification of localizated MR-spectroscopic measurement. Results - At 3T our method resulted in 37.6±0.5 mol/l and 46.4±1.5 mol/l tissue water content in the white and gray matter, respectively. Calibration based on water content led to following metabolite concentrations: N-acetyl-aspartate 7.79±0.67 mmol/l; creatine 3.76±0.28 mmol/l; choline 3.68±0.47 mmol/l; myo-inositol 10.35±3.70 mmol/l in the white matter; and N-acetyl-aspartate 8.20±0.45 mmol/l; creatine 4.76±0.18 mmol/l; choline 2.64±0.35 mmol/l; myo-inositol 8.32±1.42 mmol/l in the grey matter. Conclusions - Tissue water content based on T 1 value at 3T shows good accordance with gravimetric or other MR methods in the literature. Using it as an internal reference resulted in white matter metabolite concentrations that are in the range of previously published data. Comparing metabolite values of grey matter is more difficult because data in the literature substantially differ. The presented method is simple and easily applicable on any MR scanner without complicated correction and calibration steps.

Original languageHungarian
Pages (from-to)325-332
Number of pages8
JournalIdeggyógyászati szemle
Volume65
Issue number9-10
Publication statusPublished - Sep 30 2012

Fingerprint

Water
Creatine
Inositol
Choline
Calibration
Proton Magnetic Resonance Spectroscopy
Volunteers
Brain
Gray Matter
White Matter
N-acetylaspartate

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

T 1-relaxációs ido{combining double acute accent}n alapuló agyi víztartalom-meghatározás és kvantitatív 1H-MRS 3 T térero{combining double acute accent}n. / File, Györgyi; Bajzik, Gábor; Dóczi, T.; Orsi, Gergely; Perlaki, Gábor; Lelovics, Zsuzsanna; Aradi, Míhaly; Schwarcz, Attila.

In: Ideggyógyászati szemle, Vol. 65, No. 9-10, 30.09.2012, p. 325-332.

Research output: Contribution to journalArticle

File, Györgyi ; Bajzik, Gábor ; Dóczi, T. ; Orsi, Gergely ; Perlaki, Gábor ; Lelovics, Zsuzsanna ; Aradi, Míhaly ; Schwarcz, Attila. / T 1-relaxációs ido{combining double acute accent}n alapuló agyi víztartalom-meghatározás és kvantitatív 1H-MRS 3 T térero{combining double acute accent}n. In: Ideggyógyászati szemle. 2012 ; Vol. 65, No. 9-10. pp. 325-332.
@article{bda16b426a314cbbbee70cc02c5ce931,
title = "T 1-relax{\'a}ci{\'o}s ido{combining double acute accent}n alapul{\'o} agyi v{\'i}ztartalom-meghat{\'a}roz{\'a}s {\'e}s kvantitat{\'i}v 1H-MRS 3 T t{\'e}rero{combining double acute accent}n",
abstract = "Objective - Application of a quantitative MR-spectroscopic method for 3T clinical scanners based on tissue water content as an internal reference. Patients and methods - Six (22 ± 2 yrs) volunteers were involved in the study. We performed T 1 relaxation time measurements in a particular slice of the brain at 1T and 3T. Based on the validated water content measurement at 1T, the correlation of relaxation time T 1 and water content was determined at 3T. The resulting water content served as internal reference for the quantification of localizated MR-spectroscopic measurement. Results - At 3T our method resulted in 37.6±0.5 mol/l and 46.4±1.5 mol/l tissue water content in the white and gray matter, respectively. Calibration based on water content led to following metabolite concentrations: N-acetyl-aspartate 7.79±0.67 mmol/l; creatine 3.76±0.28 mmol/l; choline 3.68±0.47 mmol/l; myo-inositol 10.35±3.70 mmol/l in the white matter; and N-acetyl-aspartate 8.20±0.45 mmol/l; creatine 4.76±0.18 mmol/l; choline 2.64±0.35 mmol/l; myo-inositol 8.32±1.42 mmol/l in the grey matter. Conclusions - Tissue water content based on T 1 value at 3T shows good accordance with gravimetric or other MR methods in the literature. Using it as an internal reference resulted in white matter metabolite concentrations that are in the range of previously published data. Comparing metabolite values of grey matter is more difficult because data in the literature substantially differ. The presented method is simple and easily applicable on any MR scanner without complicated correction and calibration steps.",
keywords = "3T, In vivo quantitaive brain proton MR spectroscopy, Normal brain, Relaxation time T, Tissue water content",
author = "Gy{\"o}rgyi File and G{\'a}bor Bajzik and T. D{\'o}czi and Gergely Orsi and G{\'a}bor Perlaki and Zsuzsanna Lelovics and M{\'i}haly Aradi and Attila Schwarcz",
year = "2012",
month = "9",
day = "30",
language = "Hungarian",
volume = "65",
pages = "325--332",
journal = "Ideggyogyaszati Szemle",
issn = "0019-1442",
publisher = "Ifjusagi Lap-es Konyvkiado Vallalat",
number = "9-10",

}

TY - JOUR

T1 - T 1-relaxációs ido{combining double acute accent}n alapuló agyi víztartalom-meghatározás és kvantitatív 1H-MRS 3 T térero{combining double acute accent}n

AU - File, Györgyi

AU - Bajzik, Gábor

AU - Dóczi, T.

AU - Orsi, Gergely

AU - Perlaki, Gábor

AU - Lelovics, Zsuzsanna

AU - Aradi, Míhaly

AU - Schwarcz, Attila

PY - 2012/9/30

Y1 - 2012/9/30

N2 - Objective - Application of a quantitative MR-spectroscopic method for 3T clinical scanners based on tissue water content as an internal reference. Patients and methods - Six (22 ± 2 yrs) volunteers were involved in the study. We performed T 1 relaxation time measurements in a particular slice of the brain at 1T and 3T. Based on the validated water content measurement at 1T, the correlation of relaxation time T 1 and water content was determined at 3T. The resulting water content served as internal reference for the quantification of localizated MR-spectroscopic measurement. Results - At 3T our method resulted in 37.6±0.5 mol/l and 46.4±1.5 mol/l tissue water content in the white and gray matter, respectively. Calibration based on water content led to following metabolite concentrations: N-acetyl-aspartate 7.79±0.67 mmol/l; creatine 3.76±0.28 mmol/l; choline 3.68±0.47 mmol/l; myo-inositol 10.35±3.70 mmol/l in the white matter; and N-acetyl-aspartate 8.20±0.45 mmol/l; creatine 4.76±0.18 mmol/l; choline 2.64±0.35 mmol/l; myo-inositol 8.32±1.42 mmol/l in the grey matter. Conclusions - Tissue water content based on T 1 value at 3T shows good accordance with gravimetric or other MR methods in the literature. Using it as an internal reference resulted in white matter metabolite concentrations that are in the range of previously published data. Comparing metabolite values of grey matter is more difficult because data in the literature substantially differ. The presented method is simple and easily applicable on any MR scanner without complicated correction and calibration steps.

AB - Objective - Application of a quantitative MR-spectroscopic method for 3T clinical scanners based on tissue water content as an internal reference. Patients and methods - Six (22 ± 2 yrs) volunteers were involved in the study. We performed T 1 relaxation time measurements in a particular slice of the brain at 1T and 3T. Based on the validated water content measurement at 1T, the correlation of relaxation time T 1 and water content was determined at 3T. The resulting water content served as internal reference for the quantification of localizated MR-spectroscopic measurement. Results - At 3T our method resulted in 37.6±0.5 mol/l and 46.4±1.5 mol/l tissue water content in the white and gray matter, respectively. Calibration based on water content led to following metabolite concentrations: N-acetyl-aspartate 7.79±0.67 mmol/l; creatine 3.76±0.28 mmol/l; choline 3.68±0.47 mmol/l; myo-inositol 10.35±3.70 mmol/l in the white matter; and N-acetyl-aspartate 8.20±0.45 mmol/l; creatine 4.76±0.18 mmol/l; choline 2.64±0.35 mmol/l; myo-inositol 8.32±1.42 mmol/l in the grey matter. Conclusions - Tissue water content based on T 1 value at 3T shows good accordance with gravimetric or other MR methods in the literature. Using it as an internal reference resulted in white matter metabolite concentrations that are in the range of previously published data. Comparing metabolite values of grey matter is more difficult because data in the literature substantially differ. The presented method is simple and easily applicable on any MR scanner without complicated correction and calibration steps.

KW - 3T

KW - In vivo quantitaive brain proton MR spectroscopy

KW - Normal brain

KW - Relaxation time T

KW - Tissue water content

UR - http://www.scopus.com/inward/record.url?scp=84868326032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868326032&partnerID=8YFLogxK

M3 - Article

C2 - 23126218

AN - SCOPUS:84868326032

VL - 65

SP - 325

EP - 332

JO - Ideggyogyaszati Szemle

JF - Ideggyogyaszati Szemle

SN - 0019-1442

IS - 9-10

ER -